InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc5a5

Summary

InnateDB Gene

IDBG-164707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc5a5

Gene Name

solute carrier family 5 (sodium iodide symporter), member 5

Synonyms

NIS

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000792

Encoded Proteins

IDBP-164709

solute carrier family 5 (sodium iodide symporter), member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105641:
This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:70882889-70892757

Strand

Reverse strand

Band

B3.3

Transcripts

ENSMUST00000000809

ENSMUSP00000000809

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008507	sodium:iodide symporter activity
GO:0015111	iodide transmembrane transporter activity
GO:0015293	symporter activity

Biological Process

GO:0006810	transport
GO:0015705	iodide transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071371	cellular response to gonadotropin stimulus