Homo sapiens Gene: CLEC4C | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||
InnateDB Gene | IDBG-16472.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CLEC4C | ||||||||||||||||||
Gene Name | C-type lectin domain family 4, member C | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000198178 | ||||||||||||||||||
Encoded Proteins |
C-type lectin domain family 4, member C
C-type lectin domain family 4, member C
C-type lectin domain family 4, member C
C-type lectin domain family 4, member C
C-type lectin domain family 4, member C
C-type lectin domain family 4, member C
|
||||||||||||||||||
Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||
Summary |
CLEC4C (BDCA-2) signalling inhibits TLR-9-agonist-induced plasmacytoid dendritic cell activation (through the inhibition of CD86 and CD40) and antigen presentation.
|
||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
||||||||||||||||||
Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 12:7729415-7751605 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | p13.31 | ||||||||||||||||||
Transcripts |
|
||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
Biological Process |
|
||||||||||||||||||
Cellular Component |
|
||||||||||||||||||
Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q8WTT0 | ||||||||||||||||||
TrEMBL | H0YFH6 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 170482 | ||||||||||||||||||
UniGene | Hs.351812 | ||||||||||||||||||
RefSeq | NM_130441 NM_203503 | ||||||||||||||||||
HUGO | HGNC:13258 | ||||||||||||||||||
OMIM | 606677 | ||||||||||||||||||
CCDS | CCDS8583 CCDS8584 | ||||||||||||||||||
HPRD | 09453 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC006517 AF293615 AF325459 AF325460 AY358223 BC074967 BC074968 BC102015 BC102016 BC102017 BC114338 CH471116 | ||||||||||||||||||
GenPept | AAH74967 AAH74968 AAI02016 AAI02017 AAI02018 AAI14339 AAL37036 AAL37358 AAL37359 AAQ88590 EAW88655 EAW88656 | ||||||||||||||||||
RNA Seq Atlas | 170482 | ||||||||||||||||||