InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myo9b

Summary

InnateDB Gene

IDBG-164984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo9b

Gene Name

myosin IXb

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004677

Encoded Proteins

IDBP-164988

myosin IXb

IDBP-620661

myosin IXb

IDBP-620662

myosin IXb

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099331:
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:71272714-71360712

Strand

Forward strand

Band

B3.3

Transcripts

ENSMUST00000071935	ENSMUSP00000071827
ENSMUST00000170242	ENSMUSP00000129220
ENSMUST00000168839	ENSMUSP00000131635

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005096	GTPase activator activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016887	ATPase activity
GO:0030898	actin-dependent ATPase activity
GO:0043008	ATP-dependent protein binding
GO:0043531	ADP binding
GO:0046872	metal ion binding
GO:0051015	actin filament binding

Biological Process

GO:0002548	monocyte chemotaxis
GO:0006200	ATP catabolic process
GO:0007165	signal transduction
GO:0007266	Rho protein signal transduction
GO:0008152	metabolic process
GO:0030010	establishment of cell polarity
GO:0032321	positive regulation of Rho GTPase activity
GO:0035556	intracellular signal transduction
GO:0048246	macrophage chemotaxis
GO:0072673	lamellipodium morphogenesis

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005884	actin filament
GO:0005938	cell cortex
GO:0016020	membrane
GO:0016459	myosin complex
GO:0030027	lamellipodium
GO:0031941	filamentous actin
GO:0032433	filopodium tip
GO:0048471	perinuclear region of cytoplasm