Version 5.4
Mus musculus Gene: Nfu1
Summary
InnateDB Gene IDBG-165297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nfu1
Gene Name NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
Synonyms 0610006G17Rik; CGI-33; Hirip5
Species Mus musculus
Ensembl Gene ENSMUSG00000029993
Encoded Proteins
IDBP-165299
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
IDBP-400988
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
IDBP-400987
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
IDBP-536460
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169599:
This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:87009236-87028461
Strand Forward strand
Band D1
Transcripts
ENSMUST00000032060 ENSMUSP00000032060
ENSMUST00000120240 ENSMUSP00000113637
ENSMUST00000117583 ENSMUSP00000113332
ENSMUST00000144776 ENSMUSP00000121746
ENSMUST00000140343
ENSMUST00000127819
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0016226 iron-sulfur cluster assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169599
View Gene Order
ENSBTAG00000000141
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.309533
RefSeq NM_001170591 NM_020045 XM_006506419 XM_006506420
OMIM
CCDS CCDS51836
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca