InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itk

Summary

InnateDB Gene

IDBG-165583.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itk

Gene Name

IL2 inducible T cell kinase

Synonyms

Emt; Tcsk; Tsk

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020395

Encoded Proteins

IDBP-165585

IL2-inducible T-cell kinase

IDBP-165587

IL2-inducible T-cell kinase

IDBP-262823

IL2-inducible T-cell kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113263:
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:46325150-46389515

Strand

Reverse strand

Band

B1.1

Transcripts

ENSMUST00000020664	ENSMUSP00000020664
ENSMUST00000101306	ENSMUSP00000098864
ENSMUST00000109237	ENSMUSP00000104860
ENSMUST00000155991

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0001816	cytokine production
GO:0001865	NK T cell differentiation
GO:0002250	adaptive immune response
GO:0006468	protein phosphorylation
GO:0007202	activation of phospholipase C activity
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032609	interferon-gamma production
GO:0032633	interleukin-4 production
GO:0035556	intracellular signal transduction
GO:0050852	T cell receptor signaling pathway