InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc6a3

Summary

InnateDB Gene

IDBG-165714.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc6a3

Gene Name

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Synonyms

DAT; Dat1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021609

Encoded Proteins

IDBP-165716

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142319:
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3\' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:73536747-73578672

Strand

Forward strand

Band

Transcripts

ENSMUST00000022100

ENSMUSP00000022100

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005102	receptor binding
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005329	dopamine transmembrane transporter activity
GO:0005330	dopamine:sodium symporter activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008504	monoamine transmembrane transporter activity
GO:0032403	protein complex binding
GO:0035240	dopamine binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0007568	aging
GO:0007595	lactation
GO:0007608	sensory perception of smell
GO:0007626	locomotory behavior
GO:0010039	response to iron ion
GO:0014070	response to organic cyclic compound
GO:0015844	monoamine transport
GO:0015872	dopamine transport
GO:0021984	adenohypophysis development
GO:0035094	response to nicotine
GO:0040018	positive regulation of multicellular organism growth
GO:0042053	regulation of dopamine metabolic process
GO:0042220	response to cocaine
GO:0042416	dopamine biosynthetic process
GO:0042420	dopamine catabolic process
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0051591	response to cAMP
GO:0055085	transmembrane transport
GO:0060134	prepulse inhibition

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043005	neuron projection
GO:0043025	neuronal cell body