Version 5.4
| Mus musculus Gene: Frat2 | |||||||
|---|---|---|---|---|---|---|---|
| Summary | |||||||
| InnateDB Gene | IDBG-166307.7 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Frat2 | ||||||
| Gene Name | frequently rearranged in advanced T cell lymphomas 2 | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000047604 | ||||||
| Encoded Proteins |
frequently rearranged in advanced T-cell lymphomas 2
|
||||||
| Protein Structure |
|
||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181274:
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008] |
||||||
| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 19:41845978-41848132 | ||||||
| Strand | Reverse strand | ||||||
| Band | C3 | ||||||
| Transcripts |
|
||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
||||||
| Gene Ontology | |||||||
Molecular Function |
|
||||||
| Biological Process |
|
||||||
| Cellular Component |
|
||||||
| Orthologs | |||||||
|
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||
| Pathways | |||||||
| NETPATH | |||||||
| REACTOME |
Disease pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Signaling by Wnt pathway
Beta-catenin phosphorylation cascade pathway
Signaling by WNT in cancer pathway
Degradation of beta-catenin by the destruction complex pathway
AMER1 mutants destabilize the destruction complex pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
APC truncation mutants have impaired AXIN binding pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
AXIN missense mutants destabilize the destruction complex pathway
TCF dependent signaling in response to WNT pathway
APC truncation mutants are not K63 polyubiquitinated pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
TCF7L2 mutants don't bind CTBP pathway
truncations of AMER1 destabilize the destruction complex pathway
Signal Transduction pathway
truncated APC mutants destabilize the destruction complex pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
|
||||||
| KEGG |
Wnt signaling pathway pathway
|
||||||
| INOH |
Wnt signaling pathway pathway
|
||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH |
Wnt pathway
|
||||||
| REACTOME |
Beta-catenin phosphorylation cascade pathway
Degradation of beta-catenin by the destruction complex pathway
truncated APC mutants destabilize the destruction complex pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
APC truncation mutants have impaired AXIN binding pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Signal Transduction pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
|
||||||
| KEGG |
Wnt signaling pathway pathway
|
||||||
| INOH |
Wnt signaling pathway pathway
|
||||||
| PID NCI | |||||||
| Cross-References | |||||||
| SwissProt | Q8K025 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 212398 | ||||||
| UniGene | Mm.222723 | ||||||
| RefSeq | NM_177603 | ||||||
| OMIM | |||||||
| CCDS | CCDS29813 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | MGI:2673967 | ||||||
| MGI Symbol | Frat2 | ||||||
| EMBL | AK081171 AY518895 BC034214 BC085510 | ||||||
| GenPept | AAH34214 AAH85510 AAR99812 BAC38155 | ||||||
| RNA Seq Atlas | 212398 | ||||||