Version 5.4
Mus musculus Gene: Foxd3
Summary
InnateDB Gene IDBG-166471.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Foxd3
Gene Name forkhead box D3
Synonyms CWH3; Genesis; Hfh2
Species Mus musculus
Ensembl Gene ENSMUSG00000067261
Encoded Proteins
IDBP-166473
forkhead box D3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187140:
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99656299-99658622
Strand Forward strand
Band C6
Transcripts
ENSMUST00000087285 ENSMUSP00000084541
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001755 neural crest cell migration
GO:0001822 kidney development
GO:0001829 trophectodermal cell differentiation
GO:0001892 embryonic placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007389 pattern specification process
GO:0007422 peripheral nervous system development
GO:0030318 melanocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048484 enteric nervous system development
GO:0048485 sympathetic nervous system development
GO:0048846 axon extension involved in axon guidance
GO:0048937 lateral line nerve glial cell development
GO:0050935 iridophore differentiation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051216 cartilage development
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187140
View Gene Order
ENSBTAG00000008501
Not yet available
Pathways
NETPATH
REACTOME
REACT_220962
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
REACT_216222
Transcriptional regulation of pluripotent stem cells pathway
REACT_188576
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
REACT_200759
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q61060
TrEMBL A2BDY3
UniProt Splice Variant
Entrez Gene 15221
UniGene Mm.4758
RefSeq NM_010425
OMIM
CCDS CCDS18383
HPRD
IMGT
MGI ID MGI:1347473
MGI Symbol Foxd3
EMBL AF067421 BX005053 U41047
GenPept AAA87569 AAC28352
RNA Seq Atlas 15221

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca