Version 5.4
Mus musculus Gene: Otub2
Summary
InnateDB Gene IDBG-166629.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Otub2
Gene Name OTU domain, ubiquitin aldehyde binding 2
Synonyms 2010015L18Rik; 4930586I02Rik; AI413508; AW557219; OTB2; OTU2
Species Mus musculus
Ensembl Gene ENSMUSG00000021203
Encoded Proteins
IDBP-166631
OTU domain, ubiquitin aldehyde binding 2
IDBP-166633
OTU domain, ubiquitin aldehyde binding 2
IDBP-533143
OTU domain, ubiquitin aldehyde binding 2
IDBP-712347
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19996094
[Homo sapiens] OTUB2 and OTUB1 negatively regulate virus-triggered type I interferon (IFN) induction and cellular antiviral response by deubiquitinating TRAF3 and -6.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089723:
This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:103388682-103406350
Strand Forward strand
Band E
Transcripts
ENSMUST00000021620 ENSMUSP00000021620
ENSMUST00000101094 ENSMUSP00000098655
ENSMUST00000141055
ENSMUST00000148371 ENSMUSP00000115673
ENSMUST00000179684 ENSMUSP00000137162
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0008242 omega peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006520 cellular amino acid metabolic process
GO:0016579 protein deubiquitination
GO:0019538 protein metabolic process
GO:0035871 protein K11-linked deubiquitination
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000089723
View Gene Order
ENSBTAG00000014981
Not yet available
Cross-References
SwissProt
TrEMBL D3Z0Y8
UniProt Splice Variant
Entrez Gene 68149
UniGene Mm.396993 Mm.418637
RefSeq XM_006516185 NM_001177841 NM_026580
OMIM
CCDS CCDS49150 CCDS36528
HPRD
IMGT
MGI ID MGI:1915399
MGI Symbol Otub2
EMBL AC154347 AC160131
GenPept
RNA Seq Atlas 68149

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca