Version 5.4
Mus musculus Gene: Jak3
Summary
InnateDB Gene IDBG-166648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Jak3
Gene Name Janus kinase 3
Synonyms fae; wil
Species Mus musculus
Ensembl Gene ENSMUSG00000031805
Encoded Proteins
IDBP-166650
Janus kinase 3
IDBP-261165
Janus kinase 3
IDBP-261167
Janus kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22359619
Jak3 inhibition is sufficient to counteract lung injury and protect immunocytes from hypercytokinemia following challenge with avian influenza H5N1 hemagglutinin.
InnateDB Annotation from Orthologs
Summary
PMID 14976041
[Homo sapiens] JAK3 is a primary response gene for IL6 in macrophage differentiation and ectopic overexpression of JAK3 accelerates monocytic differentiation of normal mouse bone marrow cells stimulated with cytokines.
PMID 22359619
[Homo sapiens] JAK3 inhibition is sufficient to counteract lung injury and protect immunocytes from hypercytokinemia following challenge with avian influenza H5N1 hemagglutinin.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105639:
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:71676296-71690575
Strand Forward strand
Band B3.3
Transcripts
ENSMUST00000051995 ENSMUSP00000060073
ENSMUST00000110013 ENSMUSP00000105640
ENSMUST00000110012 ENSMUSP00000105639
ENSMUST00000133263
ENSMUST00000130624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 18 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019903 protein phosphatase binding
Biological Process
GO:0002731 negative regulation of dendritic cell cytokine production
GO:0006468 protein phosphorylation
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030183 B cell differentiation
GO:0032693 negative regulation of interleukin-10 production
GO:0032695 negative regulation of interleukin-12 production
GO:0035556 intracellular signal transduction
GO:0035771 interleukin-4-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042506 tyrosine phosphorylation of Stat5 protein
GO:0043029 T cell homeostasis
GO:0045087 innate immune response (InnateDB)
GO:0045221 negative regulation of FasL biosynthetic process
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046777 protein autophosphorylation
GO:0048535 lymph node development
GO:0050778 positive regulation of immune response
GO:0050868 negative regulation of T cell activation
GO:0051928 positive regulation of calcium ion transport
GO:0070232 regulation of T cell apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070669 response to interleukin-2
GO:0070670 response to interleukin-4
GO:0070672 response to interleukin-15
GO:0071104 response to interleukin-9
GO:2000670 positive regulation of dendritic cell apoptotic process
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0012505 endomembrane system
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105639
View Gene Order
ENSBTAG00000020904
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_261365
Interleukin-2 signaling pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_210793
Interleukin receptor SHC signaling pathway
REACT_261687
Signaling by Interleukins pathway
REACT_198701
Interleukin-7 signaling pathway
REACT_207835
G-protein beta:gamma signalling pathway
REACT_225836
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_188257
Signal Transduction pathway
REACT_223974
G beta:gamma signalling through PI3Kgamma pathway
KEGG
mmu04630
Jak-STAT signaling pathway pathway
mmu05340
Primary immunodeficiency pathway
mmu04062
Chemokine signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
IL-4 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-2 signaling pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_14
IL2 pathway
NetPath_16
IL4 pathway
NetPath_19
IL-7 pathway
NetPath_20
IL9 pathway
NetPath_22
Leptin pathway
REACTOME
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_115529
Interleukin-7 signaling pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_604
Hemostasis pathway
KEGG
hsa04630
Jak-STAT signaling pathway pathway
hsa05340
Primary immunodeficiency pathway
hsa04062
Chemokine signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
IL-4 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-2 signaling pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
cd40_pathway
CD40/CD40L signaling
il2_1pathway
IL2-mediated signaling events
tcptp_pathway
Signaling events mediated by TCPTP
il4_2pathway
IL4-mediated signaling events
shp2_pathway
SHP2 signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
il2_pi3kpathway
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.249645
RefSeq NM_001190830 NM_010589
OMIM
CCDS CCDS22403
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca