Version 5.4
Mus musculus Gene: Atp7a
Summary
InnateDB Gene IDBG-166773.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atp7a
Gene Name ATPase, Cu++ transporting, alpha polypeptide
Synonyms MNK
Species Mus musculus
Ensembl Gene ENSMUSG00000033792
Encoded Proteins
IDBP-166775
ATPase, Cu++ transporting, alpha polypeptide
IDBP-253630
ATPase, Cu++ transporting, alpha polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165240:
This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked cutis laxa, and occipital horn syndrome. [provided by RefSeq, Oct 2011]
This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:106027276-106124926
Strand Forward strand
Band D
Transcripts
ENSMUST00000055941 ENSMUSP00000058840
ENSMUST00000113557 ENSMUSP00000109186
ENSMUST00000134363
ENSMUST00000133875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004008 copper-exporting ATPase activity
GO:0005375 copper ion transmembrane transporter activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016532 superoxide dismutase copper chaperone activity
GO:0019829 cation-transporting ATPase activity
GO:0032767 copper-dependent protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001568 blood vessel development
GO:0001701 in utero embryonic development
GO:0001836 release of cytochrome c from mitochondria
GO:0001974 blood vessel remodeling
GO:0002082 regulation of oxidative phosphorylation
GO:0006568 tryptophan metabolic process
GO:0006570 tyrosine metabolic process
GO:0006584 catecholamine metabolic process
GO:0006812 cation transport
GO:0006825 copper ion transport
GO:0006878 cellular copper ion homeostasis
GO:0007005 mitochondrion organization
GO:0007595 lactation
GO:0007626 locomotory behavior
GO:0010041 response to iron(III) ion
GO:0010043 response to zinc ion
GO:0010273 detoxification of copper ion
GO:0010468 regulation of gene expression
GO:0015677 copper ion import
GO:0015679 plasma membrane copper ion transport
GO:0018205 peptidyl-lysine modification
GO:0019430 removal of superoxide radicals
GO:0021702 cerebellar Purkinje cell differentiation
GO:0021860 pyramidal neuron development
GO:0021954 central nervous system neuron development
GO:0030001 metal ion transport
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0031069 hair follicle morphogenesis
GO:0042093 T-helper cell differentiation
GO:0042414 epinephrine metabolic process
GO:0042415 norepinephrine metabolic process
GO:0042417 dopamine metabolic process
GO:0042421 norepinephrine biosynthetic process
GO:0042428 serotonin metabolic process
GO:0043085 positive regulation of catalytic activity
GO:0043473 pigmentation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043588 skin development
GO:0046034 ATP metabolic process
GO:0046688 response to copper ion
GO:0048251 elastic fiber assembly
GO:0048286 lung alveolus development
GO:0048553 negative regulation of metalloenzyme activity
GO:0048554 positive regulation of metalloenzyme activity
GO:0048812 neuron projection morphogenesis
GO:0048813 dendrite morphogenesis
GO:0051216 cartilage development
GO:0051353 positive regulation of oxidoreductase activity
GO:0051542 elastin biosynthetic process
GO:0060003 copper ion export
Cellular Component
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030140 trans-Golgi network transport vesicle
GO:0030141 secretory granule
GO:0031410 cytoplasmic vesicle
GO:0031526 brush border membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165240
View Gene Order
ENSBTAG00000010018
Not yet available
Pathways
NETPATH
REACTOME
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_250224
Ion transport by P-type ATPases pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25149
Ion transport by P-type ATPases pathway
REACT_120956
Cellular responses to stress pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.254297
RefSeq NM_001109757 NM_009726
OMIM
CCDS CCDS41097 CCDS53169
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca