Version 5.4
| Homo sapiens Gene: TLE2 | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-16680.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | TLE2 | ||||||||||||||||||
| Gene Name | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) | ||||||||||||||||||
| Synonyms | ESG; ESG2; GRG2 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000065717 | ||||||||||||||||||
| Encoded Proteins |
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
|
||||||||||||||||||
| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary | Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs. | ||||||||||||||||||
| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 19:2997638-3047635 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p13.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
| Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
| Biological Process |
|
||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||
| Orthologs | |||||||||||||||||||
|
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
NOTCH1 Intracellular Domain Regulates Transcription pathway
Degradation of beta-catenin by the destruction complex pathway
truncated APC mutants destabilize the destruction complex pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
Signaling by NOTCH1 in Cancer pathway
APC truncation mutants have impaired AXIN binding pathway
deactivation of the beta-catenin transactivating complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
repression of WNT target genes pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
formation of the beta-catenin:TCF transactivating complex pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
|
||||||||||||||||||
| KEGG | |||||||||||||||||||
| INOH |
Wnt signaling pathway pathway
TGF-beta signaling pathway
|
||||||||||||||||||
| PID NCI |
Regulation of nuclear beta catenin signaling and target gene transcription
|
||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.332173 | ||||||||||||||||||
| RefSeq | NM_001144761 NM_001144762 NM_001300846 NM_003260 XM_005259636 XM_006722864 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS45911 CCDS45912 CCDS45913 CCDS74255 | ||||||||||||||||||
| HPRD | 03025 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||