Version 5.4
Homo sapiens Gene: GRB10
Summary
InnateDB Gene IDBG-16688.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRB10
Gene Name growth factor receptor-bound protein 10
Synonyms Grb-10; GRB-IR; IRBP; MEG1; RSS
Species Homo sapiens
Ensembl Gene ENSG00000106070
Encoded Proteins
IDBP-16690
growth factor receptor-bound protein 10
IDBP-16692
growth factor receptor-bound protein 10
IDBP-232144
growth factor receptor-bound protein 10
IDBP-232146
growth factor receptor-bound protein 10
IDBP-293581
growth factor receptor-bound protein 10
IDBP-293584
growth factor receptor-bound protein 10
IDBP-293558
growth factor receptor-bound protein 10
IDBP-293551
growth factor receptor-bound protein 10
IDBP-293559
growth factor receptor-bound protein 10
IDBP-293557
growth factor receptor-bound protein 10
IDBP-375435
growth factor receptor-bound protein 10
IDBP-375439
growth factor receptor-bound protein 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:50590063-50793462
Strand Reverse strand
Band p12.1
Transcripts
ENST00000335866 ENSP00000338543
ENST00000357271 ENSP00000349818
ENST00000398812 ENSP00000381793
ENST00000398810 ENSP00000381790
ENST00000401949 ENSP00000385770
ENST00000403097 ENSP00000385544
ENST00000402578 ENSP00000385189
ENST00000406641 ENSP00000385366
ENST00000407526 ENSP00000385046
ENST00000402497 ENSP00000385748
ENST00000428711 ENSP00000410920
ENST00000439044 ENSP00000413023
ENST00000461886
ENST00000473696
ENST00000482397
ENST00000465602
ENST00000483819
ENST00000470992
ENST00000483157
ENST00000492265
ENST00000467386
ENST00000478162
ENST00000490051
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032868 response to insulin
GO:0042326 negative regulation of phosphorylation
GO:0042327 positive regulation of phosphorylation
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0046325 negative regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048009 insulin-like growth factor receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020176
View Gene Order
ENSBTAG00000017086
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
REACTOME
REACT_508
Signal attenuation pathway
REACT_570
IRS activation pathway
REACT_1661
SHC activation pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_999
SHC-related events pathway
REACT_111102
Signal Transduction pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
KEGG
INOH
PID NCI
igf1_pathway
IGF1 pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
ret_pathway
Signaling events regulated by Ret tyrosine kinase
pdgfrbpathway
PDGFR-beta signaling pathway
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.164060 Hs.626978 Hs.737720
RefSeq NM_001001549 NM_001001550 NM_001001555 NM_005311 XM_005271760 XM_005271761 XM_005271765 XM_005271766 XM_005271767 XM_006715703 XM_006715704 XM_006715705
HUGO
OMIM
CCDS CCDS43582 CCDS43583 CCDS47586
HPRD 03312
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca