Version 5.4
Mus musculus Gene: Ireb2
Summary
InnateDB Gene IDBG-167179.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ireb2
Gene Name iron responsive element binding protein 2
Synonyms D9Ertd85e; Irp2
Species Mus musculus
Ensembl Gene ENSMUSG00000032293
Encoded Proteins
IDBP-167181
iron responsive element binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26190773
Macrophage iron regulatory proteins Aco1 and Ireb2 are protective against Salmonella by promoting the induction of Lcn2, a host antimicrobial factor that inhibits bacterial uptake of iron-laden siderophores, and by suppressing the ferritin iron pool.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136381:
Gene Information
Type Protein coding
Genomic Location Chromosome 9:54863755-54912534
Strand Forward strand
Band B
Transcripts
ENSMUST00000034843 ENSMUSP00000034843
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030350 iron-responsive element binding
GO:0030371 translation repressor activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006417 regulation of translation
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006879 cellular iron ion homeostasis
GO:0007568 aging
GO:0008152 metabolic process
GO:0009791 post-embryonic development
GO:0010040 response to iron(II) ion
GO:0010468 regulation of gene expression
GO:0017148 negative regulation of translation
GO:0030316 osteoclast differentiation
GO:0032526 response to retinoic acid
GO:0034101 erythrocyte homeostasis
GO:0045087 innate immune response (InnateDB)
GO:0050892 intestinal absorption
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136381
View Gene Order
ENSBTAG00000002504
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt Q811J3
TrEMBL Q8BWZ6
UniProt Splice Variant
Entrez Gene 64602
UniGene Mm.208991 Mm.400265 Mm.401765
RefSeq NM_022655
OMIM
CCDS CCDS23196
HPRD
IMGT
MGI ID MGI:1928268
MGI Symbol Ireb2
EMBL AC159892 AC161264 AF016402 AK049315 BC044665
GenPept AAC05824 AAH44665 BAC33677
RNA Seq Atlas 64602

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca