InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pcsk1

Summary

InnateDB Gene

IDBG-167978.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcsk1

Gene Name

proprotein convertase subtilisin/kexin type 1

Synonyms

Nec-1; Nec1; PC1; PC3; Phpp-1; SPC3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021587

Encoded Proteins

IDBP-167980

proprotein convertase subtilisin/kexin type 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175426:
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:75089826-75132498

Strand

Forward strand

Band

Transcripts

ENSMUST00000022075	ENSMUSP00000022075
ENSMUST00000135349

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0016485	protein processing
GO:0016486	peptide hormone processing
GO:0043043	peptide biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0030133	transport vesicle
GO:0034774	secretory granule lumen