Version 5.4
Mus musculus Gene: Tfg
Summary
InnateDB Gene IDBG-168149.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfg
Gene Name Trk-fused gene
Synonyms AI173908
Species Mus musculus
Ensembl Gene ENSMUSG00000022757
Encoded Proteins
IDBP-168151
Trk-fused gene
IDBP-401008
Trk-fused gene
IDBP-534307
Trk-fused gene
IDBP-539251
Trk-fused gene
IDBP-542597
Trk-fused gene
IDBP-541886
Trk-fused gene
IDBP-535910
Trk-fused gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114354:
There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:56690332-56717450
Strand Reverse strand
Band C1.1
Transcripts
ENSMUST00000065515 ENSMUSP00000067867
ENSMUST00000121554 ENSMUSP00000112562
ENSMUST00000127994 ENSMUSP00000121564
ENSMUST00000156522 ENSMUSP00000119884
ENSMUST00000136394 ENSMUSP00000120677
ENSMUST00000128551 ENSMUSP00000119561
ENSMUST00000141404 ENSMUSP00000117405
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007165 signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005575 cellular_component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114354
View Gene Order
ENSBTAG00000016363
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05216
Thyroid cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa05216
Thyroid cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.457126 Mm.489792
RefSeq NM_001252443 NM_019678 XM_006521980 XM_006521981
OMIM
CCDS CCDS28224
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca