Version 5.4
Mus musculus Gene: Got1
Summary
InnateDB Gene IDBG-168154.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Got1
Gene Name glutamate oxaloacetate transaminase 1, soluble
Synonyms AI789014; cAspAT; cCAT; Got-1
Species Mus musculus
Ensembl Gene ENSMUSG00000025190
Encoded Proteins
IDBP-168156
glutamate oxaloacetate transaminase 1, soluble
IDBP-536458
glutamate oxaloacetate transaminase 1, soluble
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120053:
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:43499752-43524605
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000026196 ENSMUSP00000026196
ENSMUST00000133325 ENSMUSP00000117986
ENSMUST00000132504
ENSMUST00000124954
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004609 phosphatidylserine decarboxylase activity
GO:0030170 pyridoxal phosphate binding
GO:0031406 carboxylic acid binding
GO:0047801 L-cysteine:2-oxoglutarate aminotransferase activity
GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006114 glycerol biosynthetic process
GO:0006531 aspartate metabolic process
GO:0006532 aspartate biosynthetic process
GO:0006533 aspartate catabolic process
GO:0006536 glutamate metabolic process
GO:0009058 biosynthetic process
GO:0019550 glutamate catabolic process to aspartate
GO:0019551 glutamate catabolic process to 2-oxoglutarate
GO:0032869 cellular response to insulin stimulus
GO:0043648 dicarboxylic acid metabolic process
GO:0051384 response to glucocorticoid
GO:0055089 fatty acid homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0043679 axon terminus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120053
View Gene Order
ENSBTAG00000011960
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_261601
Glucose metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_202492
Sulfur amino acid metabolism pathway
REACT_199099
Methionine salvage pathway pathway
REACT_263230
Gluconeogenesis pathway
REACT_203949
Glycogen storage diseases pathway
REACT_253147
Metabolism of polyamines pathway
REACT_239550
Amino acid synthesis and interconversion (transamination) pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu00350
Tyrosine metabolism pathway
mmu00330
Arginine and proline metabolism pathway
mmu00360
Phenylalanine metabolism pathway
mmu00400
Phenylalanine, tyrosine and tryptophan biosynthesis pathway
mmu00250
Alanine, aspartate and glutamate metabolism pathway
mmu00270
Cysteine and methionine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1520
Gluconeogenesis pathway
REACT_75881
Methionine salvage pathway pathway
REACT_14820
Metabolism of polyamines pathway
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_115639
Sulfur amino acid metabolism pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
REACT_221274
Metabolism of carbohydrates pathway
REACT_226362
Metabolism of amino acids and derivatives pathway
REACT_219973
Myoclonic epilepsy of Lafora pathway
REACT_202865
Methionine salvage pathway pathway
REACT_212045
Sulfur amino acid metabolism pathway
REACT_227222
Gluconeogenesis pathway
REACT_211129
Glycogen storage diseases pathway
REACT_224672
Glucose metabolism pathway
REACT_219139
Metabolism pathway
REACT_215919
Metabolism of polyamines pathway
REACT_217400
Amino acid synthesis and interconversion (transamination) pathway
REACT_207087
Disease pathway
KEGG
hsa00360
Phenylalanine metabolism pathway
hsa00330
Arginine and proline metabolism pathway
hsa00400
Phenylalanine, tyrosine and tryptophan biosynthesis pathway
hsa00350
Tyrosine metabolism pathway
hsa00270
Cysteine and methionine metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
INOH website
Phenylalanine degradation pathway
INOH website
Arginine Proline metabolism pathway
INOH website
Methionine Cysteine metabolism pathway
INOH website
Alanine Aspartate Asparagine metabolism pathway
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.19039 Mm.472857
RefSeq NM_010324
OMIM
CCDS CCDS29832
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca