InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gjb6

Summary

InnateDB Gene

IDBG-168295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gjb6

Gene Name

gap junction protein, beta 6

Synonyms

AA958971; Cx30; D14Bwg0506e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040055

Encoded Proteins

IDBP-168297

gap junction protein, beta 6

IDBP-537728

gap junction protein, beta 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121742:
Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:57123303-57133611

Strand

Reverse strand

Band

Transcripts

ENSMUST00000039380	ENSMUSP00000035630
ENSMUST00000160703	ENSMUSP00000124927
ENSMUST00000162931

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007154	cell communication
GO:0007568	aging
GO:0007605	sensory perception of sound
GO:0008285	negative regulation of cell proliferation
GO:0032496	response to lipopolysaccharide
GO:0042471	ear morphogenesis
GO:0048839	inner ear development
GO:0051602	response to electrical stimulus
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005829	cytosol
GO:0005921	gap junction
GO:0005922	connexon complex
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000121742

View Gene Order

ENSBTAG00000038662

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_9509

Gap junction assembly pathway

REACT_9411

Gap junction trafficking pathway

REACT_9480

Gap junction trafficking and regulation pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.25652 Mm.398972

RefSeq

NM_001010937 NM_001271663 NM_008128 XM_006518560 XM_006518561

OMIM

CCDS

CCDS27154

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas