Version 5.4
Mus musculus Gene: Tomm70a
Summary
InnateDB Gene IDBG-168434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tomm70a
Gene Name translocase of outer mitochondrial membrane 70 homolog A (yeast)
Synonyms 2610044B22Rik; D16Ium22; D16Ium22e; D16Wsu109e; mKIAA0719; Tom70
Species Mus musculus
Ensembl Gene ENSMUSG00000022752
Encoded Proteins
IDBP-624319
translocase of outer mitochondrial membrane 70 homolog A (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20628368
[Homo sapiens] TOMM70A, a mitochondrial import receptor, interacts with MAVS upon RNA virus infection acting as a critical adaptor bridging TBK1/IRF3 to MAVS.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154174:
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:57121714-57154530
Strand Forward strand
Band C1.1
Transcripts
ENSMUST00000166897 ENSMUSP00000129186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154174
View Gene Order
ENSBTAG00000014302
Not yet available
Pathways
NETPATH
REACTOME
REACT_247926
Metabolism of proteins pathway
REACT_199101
Mitochondrial protein import pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9CZW5
TrEMBL Q80TT4
UniProt Splice Variant
Entrez Gene 28185
UniGene Mm.213292 Mm.407399
RefSeq NM_138599
OMIM
CCDS CCDS28227
HPRD
IMGT
MGI ID MGI:106295
MGI Symbol Tomm70a
EMBL AK012084 AK083586 AK122356 AK145458 AK150429 BC057096 BC139420 BC139421
GenPept AAH57096 AAI39421 AAI39422 BAB28018 BAC38960 BAC65638 BAE26448 BAE29552
RNA Seq Atlas 28185

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca