Version 5.4
Homo sapiens Gene: CLEC4A
Summary
InnateDB Gene IDBG-16844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC4A
Gene Name C-type lectin domain family 4, member A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111729
Encoded Proteins
IDBP-16846
C-type lectin domain family 4, member A
IDBP-16848
C-type lectin domain family 4, member A
IDBP-16850
C-type lectin domain family 4, member A
IDBP-16852
C-type lectin domain family 4, member A
IDBP-592870
C-type lectin domain family 4, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8123632-8138607
Strand Forward strand
Band p13.31
Transcripts
ENST00000229332 ENSP00000229332
ENST00000352620 ENSP00000247243
ENST00000360500 ENSP00000353690
ENST00000345999 ENSP00000344646
ENST00000546339 ENSP00000443082
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0030246 carbohydrate binding
Biological Process
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0045087 innate immune response
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9UMR7
TrEMBL
UniProt Splice Variant
Entrez Gene 50856
UniGene Hs.504657
RefSeq NM_194450 NM_016184 NM_194447 NM_194448
HUGO HGNC:13257
OMIM 605306
CCDS CCDS8592 CCDS41745 CCDS8590 CCDS8591
HPRD 05604
IMGT
EMBL AC006511 AC092111 AF067800 AF109146 AF200738 AF328684 AJ133532 BC074822 BC074874 BC117439 BC117441
GenPept AAF14348 AAF75560 AAG35593 AAH74822 AAH74874 AAI17440 AAI17442 AAL56016 CAB54001
RNA Seq Atlas 50856

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca