Version 5.4
| Homo sapiens Gene: SPG21 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-16930.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SPG21 | ||||||||||||||||||
| Gene Name | spastic paraplegia 21 (autosomal recessive, Mast syndrome) | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000090487 | ||||||||||||||||||
| Encoded Proteins |
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 15:64963021-64990310 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q22.31 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||||||||
| SwissProt | Q9NZD8 | ||||||||||||||||||
| TrEMBL | H0YLD7 H0YLW1 H0YML6 H3BRR0 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 51324 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_001127890 NM_001127889 NM_016630 XM_005254437 | ||||||||||||||||||
| HUGO | HGNC:20373 | ||||||||||||||||||
| OMIM | 608181 | ||||||||||||||||||
| CCDS | CCDS45279 CCDS10198 | ||||||||||||||||||
| HPRD | 10492 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC069368 AC103691 AF208861 AF212231 AK172849 AK301362 BC000244 CH471082 | ||||||||||||||||||
| GenPept | AAF64275 AAH00244 AAK14917 BAD18813 BAG62906 EAW77704 | ||||||||||||||||||
| RNA Seq Atlas | 51324 | ||||||||||||||||||