InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: S100a10

Summary

InnateDB Gene

IDBG-169560.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100a10

Gene Name

S100 calcium binding protein A10 (calpactin)

Synonyms

42C; AA409961; AL024248; CAL12; Cal1l; CLP11; p10; p11

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041959

Encoded Proteins

IDBP-169562

S100 calcium binding protein A10 (calpactin)

IDBP-621418

S100 calcium binding protein A10 (calpactin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21115493

S100a10 :: Anxa2 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce disassociation of the heterotetramer and ubiquitin-mediated degradation of S100a10.

InnateDB Annotation from Orthologs

Summary

PMID 21115493

[Homo sapiens] S100A10 :: ANXA2 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce disassociation of the heterotetramer and ubiquitin-mediated degradation of S100A10.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197747:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:93555080-93564643

Strand

Forward strand

Band

F2.1

Transcripts

ENSMUST00000045756	ENSMUSP00000036949
ENSMUST00000148400
ENSMUST00000170612	ENSMUSP00000130712

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding

Biological Process

GO:0001765	membrane raft assembly
GO:0006900	membrane budding
GO:0032855	positive regulation of Rac GTPase activity
GO:0045087	innate immune response (InnateDB)
GO:0051099	positive regulation of binding
GO:0051290	protein heterotetramerization
GO:0051496	positive regulation of stress fiber assembly
GO:0051894	positive regulation of focal adhesion assembly
GO:0071229	cellular response to acid
GO:0090002	establishment of protein localization to plasma membrane
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading