Version 5.4
Homo sapiens Gene: IL17RC
Summary
InnateDB Gene IDBG-16972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL17RC
Gene Name interleukin 17 receptor C
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163702
Encoded Proteins
IDBP-16976
interleukin 17 receptor C
IDBP-16984
interleukin 17 receptor C
IDBP-292579
interleukin 17 receptor C
IDBP-362377
interleukin 17 receptor C
IDBP-362382
interleukin 17 receptor C
IDBP-362384
interleukin 17 receptor C
IDBP-362385
interleukin 17 receptor C
IDBP-362401
interleukin 17 receptor C
IDBP-362415
interleukin 17 receptor C
IDBP-362417
interleukin 17 receptor C
IDBP-362424
interleukin 17 receptor C
IDBP-362429
interleukin 17 receptor C
IDBP-362432
interleukin 17 receptor C
IDBP-362434
interleukin 17 receptor C
IDBP-362437
interleukin 17 receptor C
IDBP-588116
interleukin 17 receptor C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:9917074-9933630
Strand Forward strand
Band p25.3
Transcripts
ENST00000295981 ENSP00000295981
ENST00000383812 ENSP00000373323
ENST00000403601 ENSP00000384969
ENST00000451231 ENSP00000410834
ENST00000412901 ENSP00000399396
ENST00000438091 ENSP00000414609
ENST00000434756 ENSP00000394996
ENST00000451165 ENSP00000387675
ENST00000416074 ENSP00000395315
ENST00000436503 ENSP00000401128
ENST00000451271 ENSP00000412777
ENST00000424206 ENSP00000390080
ENST00000440502 ENSP00000413914
ENST00000455057 ENSP00000407894
ENST00000413608 ENSP00000396064
ENST00000469686
ENST00000466046
ENST00000483582
ENST00000481032
ENST00000497102
ENST00000494365
ENST00000498214
ENST00000476810 ENSP00000432564
ENST00000490512
ENST00000478206
ENST00000464406
ENST00000461995
ENST00000497387
ENST00000466712
ENST00000465794
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030368 interleukin-17 receptor activity
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:1900017 positive regulation of cytokine production involved in inflammatory response
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030281
View Gene Order
ENSBTAG00000033669
Not yet available
Cross-References
SwissProt Q8NAC3
TrEMBL
UniProt Splice Variant
Entrez Gene 84818
UniGene Hs.129959 Hs.714274
RefSeq NM_001203263 XM_006713347 XM_006713349 NM_001203264 NM_001203265 NM_032732 NM_153460 NM_153461 XM_006713346 XM_006713355 XM_006713356
HUGO HGNC:18358
OMIM 610925
CCDS CCDS56240 CCDS2590 CCDS2591 CCDS46746 CCDS56241 CCDS74898
HPRD 17142
IMGT
EMBL AC018809 AF458065 AK092907 AY358840 AY359098 BC006411
GenPept AAM77569 AAQ89199 AAQ89456 BAC04001
RNA Seq Atlas 102723646 84818

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca