InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ppap2b

Summary

InnateDB Gene

IDBG-169896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppap2b

Gene Name

phosphatidic acid phosphatase type 2B

Synonyms

1110003O22Rik; 2610002D05Rik; AV025606; D4Bwg0538e; D4Bwg1535e; Lpp3; Ppab2b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028517

Encoded Proteins

IDBP-169898

phosphatidic acid phosphatase type 2B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162407:
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:105157347-105232764

Strand

Forward strand

Band

Transcripts

ENSMUST00000064139

ENSMUSP00000065719

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008195	phosphatidate phosphatase activity
GO:0042392	sphingosine-1-phosphate phosphatase activity
GO:0042577	lipid phosphatase activity

Biological Process

GO:0001568	blood vessel development
GO:0001702	gastrulation with mouth forming second
GO:0001933	negative regulation of protein phosphorylation
GO:0006644	phospholipid metabolic process
GO:0007155	cell adhesion
GO:0016311	dephosphorylation
GO:0016337	single organismal cell-cell adhesion
GO:0030111	regulation of Wnt signaling pathway
GO:0034109	homotypic cell-cell adhesion
GO:0044328	canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration
GO:0044329	canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion
GO:0044330	canonical Wnt signaling pathway involved in positive regulation of wound healing
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050821	protein stabilization
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060020	Bergmann glial cell differentiation
GO:0060070	canonical Wnt signaling pathway
GO:1902068	regulation of sphingolipid mediated signaling pathway

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome