Version 5.4
Mus musculus Gene: Cetn3
Summary
InnateDB Gene IDBG-170158.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cetn3
Gene Name centrin 3
Synonyms MmCEN3
Species Mus musculus
Ensembl Gene ENSMUSG00000021537
Encoded Proteins
IDBP-170160
centrin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153140:
The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. [provided by RefSeq, Jul 2008]
The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:81783292-81797143
Strand Forward strand
Band C3
Transcripts
ENSMUST00000022009 ENSMUSP00000022009
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0008017 microtubule binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0032391 photoreceptor connecting cilium
GO:0035869 ciliary transition zone
GO:0036064 ciliary basal body
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153140
View Gene Order
ENSBTAG00000014373
Not yet available
Cross-References
SwissProt O35648
TrEMBL Q545L8
UniProt Splice Variant
Entrez Gene 12626
UniGene Mm.12481
RefSeq NM_007684
OMIM
CCDS CCDS26663
HPRD
IMGT
MGI ID MGI:1097706
MGI Symbol Cetn3
EMBL AK004532 AK006289 AK006891 BC002162 BC054097 CH466563 Y12474
GenPept AAH02162 AAH54097 BAB23351 BAB24508 BAB24781 CAA73078 EDL37143
RNA Seq Atlas 12626

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca