Version 5.4
Mus musculus Gene: Brd2
Summary
InnateDB Gene IDBG-170215.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Brd2
Gene Name bromodomain containing 2
Synonyms AW228947; D17H6S113E; Frg-1; Fsrg-1; Fsrg1; mKIAA4005; Nat; Ring3; Rnf3
Species Mus musculus
Ensembl Gene ENSMUSG00000024335
Encoded Proteins
IDBP-170217
bromodomain containing 2
IDBP-170219
bromodomain containing 2
IDBP-252176
bromodomain containing 2
IDBP-627024
bromodomain containing 2
IDBP-534814
bromodomain containing 2
IDBP-627029
bromodomain containing 2
IDBP-789845
bromodomain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204256:
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34112023-34122634
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000025193 ENSMUSP00000025193
ENSMUST00000095347 ENSMUSP00000092990
ENSMUST00000114242 ENSMUSP00000109880
ENSMUST00000154232 ENSMUSP00000128835
ENSMUST00000142570
ENSMUST00000148143
ENSMUST00000151986 ENSMUSP00000117359
ENSMUST00000155286
ENSMUST00000173032 ENSMUSP00000134608
ENSMUST00000173204 ENSMUSP00000138431
ENSMUST00000179722
ENSMUST00000177828
ENSMUST00000179687
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0006334 nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016568 chromatin modification
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000204256
View Gene Order
ENSBTAG00000011074
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3444 Mm.413858
RefSeq NM_001204973 NM_010238 XM_006523658 XM_006525302 XM_006536518 XM_006536519 XM_006537251 XM_006537252
OMIM
CCDS CCDS28641
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca