Version 5.4
Mus musculus Gene: Dhcr24
Summary
InnateDB Gene IDBG-170296.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dhcr24
Gene Name 24-dehydrocholesterol reductase
Synonyms 2310076D10Rik; 5830417J06Rik; mKIAA0018
Species Mus musculus
Ensembl Gene ENSMUSG00000034926
Encoded Proteins
IDBP-170298
24-dehydrocholesterol reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20406300
[Homo sapiens] DHCR24 (Seladin1) is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS. DHCR24 is an LPS-responsible gene product that negatively regulates the LPS-induced inflammatory response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116133:
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:106561038-106589113
Strand Forward strand
Band C7
Transcripts
ENSMUST00000047973 ENSMUSP00000038063
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0019899 enzyme binding
GO:0042605 peptide antigen binding
GO:0050614 delta24-sterol reductase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006979 response to oxidative stress
GO:0007265 Ras protein signal transduction
GO:0008104 protein localization
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0009725 response to hormone
GO:0009888 tissue development
GO:0016125 sterol metabolic process
GO:0030539 male genitalia development
GO:0031639 plasminogen activation
GO:0042987 amyloid precursor protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043588 skin development
GO:0055114 oxidation-reduction process
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116133
View Gene Order
ENSBTAG00000004688
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_208531
Cholesterol biosynthesis pathway
KEGG
mmu00100
Steroid biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9405
Cholesterol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00100
Steroid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q8VCH6
TrEMBL
UniProt Splice Variant
Entrez Gene 74754
UniGene Mm.133370 Mm.409246 Mm.411209 Mm.411568
RefSeq NM_053272
OMIM
CCDS CCDS18420
HPRD
IMGT
MGI ID MGI:1922004
MGI Symbol Dhcr24
EMBL AK017937 AK129036 AL929585 AY039762 BC019797 BX511043
GenPept AAH19797 AAK72106 BAB31012 BAC97846 CAM27475
RNA Seq Atlas 74754

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca