InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Smad1

Summary

InnateDB Gene

IDBG-170516.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smad1

Gene Name

SMAD family member 1

Synonyms

AI528653; Madh1; Madr1; Mlp1; MusMLP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031681

Encoded Proteins

IDBP-170518

MAD homolog 1 (Drosophila)

IDBP-170520

MAD homolog 1 (Drosophila)

IDBP-261441

MAD homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170365:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene \'mothers against decapentaplegic\' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:79338395-79399518

Strand

Reverse strand

Band

Transcripts

ENSMUST00000066091	ENSMUSP00000071035
ENSMUST00000066081	ENSMUSP00000064015
ENSMUST00000109885	ENSMUSP00000105511

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 118 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	118 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0070410	co-SMAD binding
GO:0070411	I-SMAD binding

Biological Process

GO:0000165	MAPK cascade
GO:0001657	ureteric bud development
GO:0001710	mesodermal cell fate commitment
GO:0001822	kidney development
GO:0002051	osteoblast fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007183	SMAD protein complex assembly
GO:0007276	gamete generation
GO:0008285	negative regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0010243	response to organonitrogen compound
GO:0010628	positive regulation of gene expression
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0030509	BMP signaling pathway
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0042060	wound healing
GO:0042493	response to drug
GO:0042592	homeostatic process
GO:0045597	positive regulation of cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050775	positive regulation of dendrite morphogenesis
GO:0051216	cartilage development
GO:0060038	cardiac muscle cell proliferation
GO:0060348	bone development
GO:0061036	positive regulation of cartilage development
GO:0071407	cellular response to organic cyclic compound
GO:0071773	cellular response to BMP stimulus
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005637	nuclear inner membrane
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0043234	protein complex