Mus musculus Gene: Ppara
Summary
InnateDB Gene IDBG-170640.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppara
Gene Name peroxisome proliferator activated receptor alpha
Synonyms 4933429D07Rik; AW742785; Nr1c1; Ppar; PPAR-alpha; PPARalpha;
Species Mus musculus
Ensembl Gene ENSMUSG00000022383
Encoded Proteins
peroxisome proliferator activated receptor alpha
peroxisome proliferator activated receptor alpha
peroxisome proliferator activated receptor alpha
Protein Structure
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186951:
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:85734983-85802819
Strand Forward strand
Band E2
Transcripts
ENSMUST00000057979 ENSMUSP00000059719
ENSMUST00000109423 ENSMUSP00000105050
ENSMUST00000109422 ENSMUSP00000105049
ENSMUST00000134880
ENSMUST00000138813
ENSMUST00000136453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004872 receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0019902 phosphatase binding
GO:0019904 protein domain specific binding
GO:0031624 ubiquitin conjugating enzyme binding
GO:0032403 protein complex binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0051525 NFAT protein binding
GO:0097371 MDM2/MDM4 family protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001666 response to hypoxia
GO:0006006 glucose metabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0007507 heart development
GO:0008544 epidermis development
GO:0010468 regulation of gene expression
GO:0010871 negative regulation of receptor biosynthetic process
GO:0010887 negative regulation of cholesterol storage
GO:0010891 negative regulation of sequestering of triglyceride
GO:0019217 regulation of fatty acid metabolic process
GO:0030522 intracellular receptor signaling pathway
GO:0032091 negative regulation of protein binding
GO:0032099 negative regulation of appetite
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0035095 behavioral response to nicotine
GO:0042060 wound healing
GO:0042157 lipoprotein metabolic process
GO:0042752 regulation of circadian rhythm
GO:0043401 steroid hormone mediated signaling pathway
GO:0045722 positive regulation of gluconeogenesis
GO:0045776 negative regulation of blood pressure
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046321 positive regulation of fatty acid oxidation
GO:0070166 enamel mineralization
GO:0072363 regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter
GO:0072366 regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:1901215 negative regulation of neuron death
GO:2000678 negative regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transcriptional regulation of white adipocyte differentiation pathway
Organelle biogenesis and maintenance pathway
Mus musculus biological processes pathway
Nuclear Receptor transcription pathway pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Circadian Clock pathway
Circadian Clock pathway
Activation of gene expression by SREBF (SREBP) pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REV-ERBA represses gene expression pathway
RORA activates circadian gene expression pathway
Orphan transporters pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Transcriptional activation of mitochondrial biogenesis pathway
Transmembrane transport of small molecules pathway
Gene Expression pathway
PPARA activates gene expression pathway
Developmental Biology pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
Generic Transcription Pathway pathway
Mitochondrial biogenesis pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Rora activates circadian gene expression pathway
Bmal1:Clock,Npas2 activates circadian gene expression pathway
KEGG
PPAR signaling pathway pathway
Adipocytokine signaling pathway pathway
Hepatitis C pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Organelle biogenesis and maintenance pathway
Developmental Biology pathway
Circadian Clock pathway
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
REV-ERBA represses gene expression pathway
Mitochondrial biogenesis pathway
PPARA activates gene expression pathway
Nuclear Receptor transcription pathway pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Generic Transcription Pathway pathway
RORA activates circadian gene expression pathway
Orphan transporters pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
Transcriptional activation of mitochondrial biogenesis pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Gene Expression pathway
KEGG
PPAR signaling pathway pathway
Adipocytokine signaling pathway pathway
Hepatitis C pathway
INOH
PID BIOCARTA
Toll-like receptor pathway [Biocarta view]
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
Regulation of pgc-1a [Biocarta view]
Ss-arrestins in gpcr desensitization [Biocarta view]
Basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression [Biocarta view]
PID NCI
Cross-References
SwissProt P23204
TrEMBL Q542P9
UniProt Splice Variant
Entrez Gene 19013
UniGene Mm.212789
RefSeq NM_001113418 NM_011144 XM_006520619
OMIM
CCDS CCDS27721
HPRD
IMGT
MGI ID MGI:104740
MGI Symbol Ppara
EMBL AK035676 AK081709 AK149460 BC016892 CH466550 X57638 X75289 X75290 X75291 X75292 X75293 X75294 X89577
GenPept AAH16892 BAC29149 BAC38303 BAE28893 CAA40856 CAA53042 CAA61754 EDL04427
ImmGen Ppara (murine)
RNA Seq Atlas 19013