InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp1a1

Summary

InnateDB Gene

IDBG-170677.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp1a1

Gene Name

cytochrome P450, family 1, subfamily a, polypeptide 1

Synonyms

AHH; AHRR; CP11; Cyp1a2; P450-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032315

Encoded Proteins

IDBP-170679

cytochrome P450, family 1, subfamily a, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140465:
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme\'s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:57697613-57703822

Strand

Forward strand

Band

Transcripts

ENSMUST00000034865

ENSMUSP00000034865

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008395	steroid hydroxylase activity
GO:0016491	oxidoreductase activity
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016711	flavonoid 3'-monooxygenase activity
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0032451	demethylase activity
GO:0070330	aromatase activity
GO:0070576	vitamin D 24-hydroxylase activity

Biological Process

GO:0001666	response to hypoxia
GO:0001889	liver development
GO:0006778	porphyrin-containing compound metabolic process
GO:0007568	aging
GO:0008283	cell proliferation
GO:0009308	amine metabolic process
GO:0009404	toxin metabolic process
GO:0009611	response to wounding
GO:0009615	response to virus
GO:0009624	response to nematode
GO:0009635	response to herbicide
GO:0009636	response to toxic substance
GO:0009792	embryo development ending in birth or egg hatching
GO:0009804	coumarin metabolic process
GO:0009812	flavonoid metabolic process
GO:0010033	response to organic substance
GO:0010041	response to iron(III) ion
GO:0014070	response to organic cyclic compound
GO:0017143	insecticide metabolic process
GO:0017144	drug metabolic process
GO:0018894	dibenzo-p-dioxin metabolic process
GO:0019341	dibenzo-p-dioxin catabolic process
GO:0032094	response to food
GO:0032496	response to lipopolysaccharide
GO:0032502	developmental process
GO:0033189	response to vitamin A
GO:0035902	response to immobilization stress
GO:0042493	response to drug
GO:0042904	9-cis-retinoic acid biosynthetic process
GO:0043010	camera-type eye development
GO:0046483	heterocycle metabolic process
GO:0046677	response to antibiotic
GO:0046685	response to arsenic-containing substance
GO:0048565	digestive tract development
GO:0050665	hydrogen peroxide biosynthetic process
GO:0055093	response to hyperoxia
GO:0055114	oxidation-reduction process
GO:0060137	maternal process involved in parturition
GO:0070365	hepatocyte differentiation
GO:0070988	demethylation
GO:0071407	cellular response to organic cyclic compound
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle