Version 5.4
Mus musculus Gene: Edil3
Summary
InnateDB Gene IDBG-170705.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Edil3
Gene Name EGF-like repeats and discoidin I-like domains 3
Synonyms Del-1; Del1
Species Mus musculus
Ensembl Gene ENSMUSG00000034488
Encoded Proteins
IDBP-170707
EGF-like repeats and discoidin I-like domains 3
IDBP-170709
EGF-like repeats and discoidin I-like domains 3
IDBP-400939
EGF-like repeats and discoidin I-like domains 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22447028
The leukocyte integrin antagonist (Edil3) Del-1 inhibits IL-17-mediated inflammatory bone loss.
InnateDB Annotation from Orthologs
Summary
PMID 22447028
[Homo sapiens] The leukocyte integrin antagonist (EDIL3) Del-1 inhibits IL-17-mediated inflammatory bone loss. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164176:
The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:88821472-89323223
Strand Forward strand
Band C3
Transcripts
ENSMUST00000081769 ENSMUSP00000080462
ENSMUST00000043111 ENSMUSP00000044652
ENSMUST00000118731 ENSMUSP00000112829
ENSMUST00000153974
ENSMUST00000134241
ENSMUST00000133761
ENSMUST00000137921
ENSMUST00000140625
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007275 multicellular organismal development
GO:0010811 positive regulation of cell-substrate adhesion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164176
View Gene Order
ENSBTAG00000044033
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
integrin3_pathway
Beta3 integrin cell surface interactions
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.125580 Mm.398055
RefSeq NM_001037987 NM_010103
OMIM
CCDS CCDS26669 CCDS26670
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca