Version 5.4
Homo sapiens Gene: NFIC
Summary
InnateDB Gene IDBG-17079.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFIC
Gene Name nuclear factor I/C (CCAAT-binding transcription factor)
Synonyms CTF; CTF5; NF-I; NFI
Species Homo sapiens
Ensembl Gene ENSG00000141905
Encoded Proteins
IDBP-17085
nuclear factor I/C (CCAAT-binding transcription factor)
IDBP-240205
nuclear factor I/C (CCAAT-binding transcription factor)
IDBP-364068
nuclear factor I/C (CCAAT-binding transcription factor)
IDBP-763891
IDBP-762009
IDBP-765136
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3359563-3469217
Strand Forward strand
Band p13.3
Transcripts
ENST00000341919 ENSP00000342194
ENST00000395111 ENSP00000378543
ENST00000443272 ENSP00000396843
ENST00000590282 ENSP00000466647
ENST00000589123 ENSP00000465655
ENST00000589537
ENST00000586919 ENSP00000465177
ENST00000589164
ENST00000588839
ENST00000589969
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001159 core promoter proximal region DNA binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006260 DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055053
View Gene Order
ENSBTAG00000008520
Not yet available
Pathways
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P08651
TrEMBL
UniProt Splice Variant
Entrez Gene 4782
UniGene Hs.170131 Hs.560695 Hs.569985 Hs.711598
RefSeq NM_001245002 NM_001245004 NM_001245005 NM_005597 NM_205843
HUGO HGNC:7786
OMIM 600729
CCDS CCDS59330 CCDS12107 CCDS45914 CCDS58640 CCDS59331
HPRD
IMGT
EMBL AC005514 AC005551 AC005778 AK289885 AK297867 AK304816 BC012120 CH471139 X12492 X92857
GenPept AAC32593 AAC32594 AAC33190 AAC33191 AAC33192 AAC62842 AAH12120 BAF82574 BAH12681 BAH14259 CAA31012 CAA63440 EAW69325 EAW69326
RNA Seq Atlas 4782

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca