Version 5.4
Mus musculus Gene: Clk3
Summary
InnateDB Gene IDBG-170844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clk3
Gene Name CDC-like kinase 3
Synonyms AI256811
Species Mus musculus
Ensembl Gene ENSMUSG00000032316
Encoded Proteins
IDBP-170846
CDC-like kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179335:
This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:57750711-57765860
Strand Reverse strand
Band B
Transcripts
ENSMUST00000065330 ENSMUSP00000067341
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043484 regulation of RNA splicing
GO:0046777 protein autophosphorylation
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0016020 membrane
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000179335
View Gene Order
ENSBTAG00000007304
Not yet available
Cross-References
SwissProt O35492
TrEMBL
UniProt Splice Variant
Entrez Gene 102414
UniGene
RefSeq NM_007713 XM_006510739
OMIM
CCDS CCDS23232
HPRD
IMGT
MGI ID MGI:1098670
MGI Symbol Clk3
EMBL AF033565 AK009908 AK090215 AK133936 AK146942 AK154003 AK167300 BC085084
GenPept AAB87509 AAH85084 BAC41138 BAE21937 BAE27551 BAE32308 BAE39405 BAE43216
RNA Seq Atlas 102414

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca