Version 5.4
Mus musculus Gene: H2-Aa
Summary
InnateDB Gene IDBG-170982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2-Aa
Gene Name histocompatibility 2, class II antigen A, alpha
Synonyms Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1; IAalpha
Species Mus musculus
Ensembl Gene ENSMUSG00000036594
Encoded Proteins
IDBP-170984
histocompatibility 2, class II antigen A, alpha
IDBP-627215
histocompatibility 2, class II antigen A, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21441935
H2-Aa is an intracellular MHC class II molecule that can act as an adaptor to promote the full activation of the TLR-triggered innate immune response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196735:
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34282744-34287827
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000040655 ENSMUSP00000046105
ENSMUST00000174751 ENSMUSP00000133399
ENSMUST00000165139
ENSMUST00000173944
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042605 peptide antigen binding
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0034341 response to interferon-gamma
GO:0045087 innate immune response (InnateDB)
GO:0045582 positive regulation of T cell differentiation
GO:0048002 antigen processing and presentation of peptide antigen
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042613 MHC class II protein complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000196735
View Gene Order
Pathways
NETPATH
REACTOME
REACT_263643
PD-1 signaling pathway
REACT_216080
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_225145
Downstream TCR signaling pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_215414
Translocation of ZAP-70 to Immunological synapse pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_229531
Adaptive Immune System pathway
REACT_225768
Generation of second messenger molecules pathway
REACT_222648
TCR signaling pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04940
Type I diabetes mellitus pathway
mmu04612
Antigen processing and presentation pathway
mmu05310
Asthma pathway
mmu05330
Allograft rejection pathway
mmu05332
Graft-versus-host disease pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05320
Autoimmune thyroid disease pathway
mmu04672
Intestinal immune network for IgA production pathway
mmu05416
Viral myocarditis pathway
mmu05150
Staphylococcus aureus infection pathway
mmu05140
Leishmaniasis pathway
mmu04145
Phagosome pathway
mmu05145
Toxoplasmosis pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_12555
Downstream TCR signaling pathway
REACT_12623
Generation of second messenger molecules pathway
REACT_12596
Translocation of ZAP-70 to Immunological synapse pathway
REACT_12582
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_25078
Interferon gamma signaling pathway
REACT_19324
PD-1 signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_12526
TCR signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04612
Antigen processing and presentation pathway
hsa04940
Type I diabetes mellitus pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05332
Graft-versus-host disease pathway
hsa05310
Asthma pathway
hsa04672
Intestinal immune network for IgA production pathway
hsa05416
Viral myocarditis pathway
hsa05140
Leishmaniasis pathway
hsa05150
Staphylococcus aureus infection pathway
hsa05145
Toxoplasmosis pathway
hsa04145
Phagosome pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
Cross-References
SwissProt P14434
TrEMBL G3UWR9
UniProt Splice Variant
Entrez Gene 14960
UniGene
RefSeq NM_010378
OMIM
CCDS CCDS28645
HPRD
IMGT
MGI ID MGI:95895
MGI Symbol H2-Aa
EMBL AF027865 AF050157 BC019721 BC031711 CR974422 K01922
GenPept AAA39614 AAB81529 AAC05285 AAH19721 AAH31711
RNA Seq Atlas 14960

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca