Mus musculus Gene: H2-Aa | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-170982.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | H2-Aa | ||||||||||||||||||||||
Gene Name | histocompatibility 2, class II antigen A, alpha | ||||||||||||||||||||||
Synonyms | Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1; IAalpha | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000036594 | ||||||||||||||||||||||
Encoded Proteins |
histocompatibility 2, class II antigen A, alpha
histocompatibility 2, class II antigen A, alpha
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
H2-Aa is an intracellular MHC class II molecule that can act as an adaptor to promote the full activation of the TLR-triggered innate immune response.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196735:
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 17:34282744-34287827 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | B1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
PD-1 signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Downstream TCR signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
MHC class II antigen presentation pathway
Translocation of ZAP-70 to Immunological synapse pathway
Costimulation by the CD28 family pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
TCR signaling pathway
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KEGG |
Cell adhesion molecules (CAMs) pathway
Type I diabetes mellitus pathway
Antigen processing and presentation pathway
Asthma pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Systemic lupus erythematosus pathway
Autoimmune thyroid disease pathway
Intestinal immune network for IgA production pathway
Viral myocarditis pathway
Staphylococcus aureus infection pathway
Leishmaniasis pathway
Phagosome pathway
Toxoplasmosis pathway
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INOH |
CD4 T cell receptor signaling pathway
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PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
MHC class II antigen presentation pathway
Downstream TCR signaling pathway
Generation of second messenger molecules pathway
Translocation of ZAP-70 to Immunological synapse pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Interferon gamma signaling pathway
PD-1 signaling pathway
Costimulation by the CD28 family pathway
TCR signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
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KEGG |
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Type I diabetes mellitus pathway
Allograft rejection pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Graft-versus-host disease pathway
Asthma pathway
Intestinal immune network for IgA production pathway
Viral myocarditis pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Toxoplasmosis pathway
Phagosome pathway
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INOH |
CD4 T cell receptor signaling pathway
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PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P14434 | ||||||||||||||||||||||
TrEMBL | G3UWR9 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 14960 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_010378 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS28645 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:95895 | ||||||||||||||||||||||
MGI Symbol | H2-Aa | ||||||||||||||||||||||
EMBL | AF027865 AF050157 BC019721 BC031711 CR974422 K01922 | ||||||||||||||||||||||
GenPept | AAA39614 AAB81529 AAC05285 AAH19721 AAH31711 | ||||||||||||||||||||||
RNA Seq Atlas | 14960 | ||||||||||||||||||||||