Version 5.4
Mus musculus Gene: Celsr1
Summary
InnateDB Gene IDBG-170993.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Celsr1
Gene Name cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
Synonyms crash; Crsh; Scy
Species Mus musculus
Ensembl Gene ENSMUSG00000016028
Encoded Proteins
IDBP-170995
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075275:
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:85898758-86033777
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000016172 ENSMUSP00000016172
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001702 gastrulation with mouth forming second
GO:0001736 establishment of planar polarity
GO:0001764 neuron migration
GO:0001843 neural tube closure
GO:0001942 hair follicle development
GO:0007156 homophilic cell adhesion
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007266 Rho protein signal transduction
GO:0007267 cell-cell signaling
GO:0007417 central nervous system development
GO:0007626 locomotory behavior
GO:0009952 anterior/posterior pattern specification
GO:0032956 regulation of actin cytoskeleton organization
GO:0042060 wound healing
GO:0042249 establishment of planar polarity of embryonic epithelium
GO:0042472 inner ear morphogenesis
GO:0045176 apical protein localization
GO:0046928 regulation of neurotransmitter secretion
GO:0048105 establishment of body hair planar orientation
GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060489 planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060490 lateral sprouting involved in lung morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090251 protein localization involved in establishment of planar polarity
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000075275
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.22680
RefSeq NM_009886 XM_006520381
OMIM
CCDS CCDS37172
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca