Version 5.4
Mus musculus Gene: Ppp2r5c
Summary
InnateDB Gene IDBG-171384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp2r5c
Gene Name protein phosphatase 2, regulatory subunit B (B56), gamma isoform
Synonyms 2610043M05Rik; 2700063L20Rik; AI060890; AW545884; C85228; D12Bwg0916e; mKIAA0044
Species Mus musculus
Ensembl Gene ENSMUSG00000017843
Encoded Proteins
IDBP-171390
protein phosphatase 2, regulatory subunit B (B56), gamma isoform
IDBP-261540
protein phosphatase 2, regulatory subunit B (B56), gamma isoform
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078304:
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:110485739-110583061
Strand Forward strand
Band F1
Transcripts
ENSMUST00000084985 ENSMUSP00000082053
ENSMUST00000109832 ENSMUSP00000105458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078304
View Gene Order
ENSBTAG00000020192
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_258066
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_214014
Signaling by Wnt pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_218396
Beta-catenin phosphorylation cascade pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_203336
Degradation of beta-catenin by the destruction complex pathway
REACT_235529
AMER1 mutants destabilize the destruction complex pathway
REACT_188804
Cell Cycle pathway
REACT_230745
Immune System pathway
REACT_241408
M Phase pathway
REACT_231507
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_258576
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_230286
APC truncation mutants have impaired AXIN binding pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_241514
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_216784
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_236203
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_234076
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_252458
AXIN missense mutants destabilize the destruction complex pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_263691
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_248000
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_261276
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_254498
TCF7L2 mutants don't bind CTBP pathway
REACT_261568
CTLA4 inhibitory signaling pathway
REACT_229531
Adaptive Immune System pathway
REACT_250714
truncations of AMER1 destabilize the destruction complex pathway
REACT_188257
Signal Transduction pathway
REACT_237096
truncated APC mutants destabilize the destruction complex pathway
REACT_260752
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_202512
Mitotic Anaphase pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
mmu04114
Oocyte meiosis pathway
mmu03015
mRNA surveillance pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_19405
CTLA4 inhibitory signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_23879
Platelet sensitization by LDL pathway
REACT_23876
Platelet homeostasis pathway
REACT_11065
Beta-catenin phosphorylation cascade pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04114
Oocyte meiosis pathway
hsa03015
mRNA surveillance pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.240396 Mm.437693 Mm.490988
RefSeq NM_001081457 NM_001081458 NM_012023 XM_006515917 XM_006515918 XM_006515922
OMIM
CCDS CCDS36557 CCDS36558
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca