Mus musculus Gene: Btk

Summary
InnateDB Gene IDBG-171427.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Btk
Gene Name Bruton agammaglobulinemia tyrosine kinase
Synonyms AI528679; xid
Species Mus musculus
Ensembl Gene ENSMUSG00000031264
Encoded Proteins
IDBP-171429 Bruton agammaglobulinemia tyrosine kinase
IDBP-254355 Bruton agammaglobulinemia tyrosine kinase
InnateDB Annotation
Summary
PMID 21441935 Btk interacts with intracellular MHC class II molecules to activate adaptor molecules Myd88 and Ticam1 to promote TLR signalling.
PMID 21659545 Btk is a positive regulator in the ITAM-mediated Trem1/Tyrobp pathway, which induces pro-inflammatory cytokines such as TNF-alpha, Il8, and activation/differentiation cell surface markers.
PMID 22454496 Btk directly phosphorylates Tlr3 and plays a critical role in the induction of inflammatory cytokines and Ifnb.
PMID 22589540 Btk is required for the activation of natural killer cells.
PMID 22366891 Btk is a negative regulator of TLR- or TNF-stimulated reactive oxygen species (ROS) production in neutrophils. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 12724322 [Homo sapiens] BTK is a Toll/interleukin-1 receptor domain-binding protein that participates in NF-kappaB activation by TLR4.
PMID 21441935 [Homo sapiens] BTK interacts with intracellular MHC class II molecules to activate adaptor molecules MYD88 and TICAM1 to promote TLR signalling. (Demonstrated in murine model)
PMID 21659545 [Homo sapiens] BTK is a positive regulator in the ITAM-mediated TREM1/TYROBP pathway, which induces pro-inflammatory cytokines such as TNF-alpha, IL8, and activation/differentiation cell surface markers. Patients suffering from X-linked agammaglobulinemia (XLA), which is a rare hereditary disease caused by mutation in the BTK gene, show reduced TNF-alpha induction in PBMCs upon TREM1 engagement.
PMID 22454496 [Homo sapiens] BTK directly phosphorylates TLR3 and plays a critical role in the induction of inflammatory cytokines and IFNB. (Demonstrated in mice)
PMID 22589540 [Homo sapiens] BTK is required for the activation of natural killer cells. (Demonstrated in mice)
PMID 22366891 [Homo sapiens] BTK is a negative regulator of TLR- or TNF-stimulated reactive oxygen species (ROS) production in neutrophils.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000010671:
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X: 134542336-134583570
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000033617  ENSMUSP00000033617
ENSMUST00000113213  ENSMUSP00000108839
ENSMUST00000132664 
ENSMUST00000150245 
ENSMUST00000128333 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein‑Protein  42
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 41 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-dependent
GO:0006355 regulation of transcription, DNA-dependent
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007249 I-kappaB kinase/NF-kappaB cascade
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
GO:0048469 cell maturation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000010671 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000019250 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_120469 Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
REACT_148808 DAP12 signaling
KEGG
mmu04662  B cell receptor signaling pathway
mmu04664  Fc epsilon RI signaling pathway
mmu04380  Osteoclast differentiation
mmu05340  Primary immunodeficiency
INOH
INOH website AKT(PKB)-Bad signaling - EPO signaling pathway (JAK2 STAT1 STAT3 STAT5)
INOH website AKT(PKB)-Bad signaling - IL-7 signaling (JAK1 JAK3 STAT5)
INOH website EPO signaling pathway (JAK2 STAT1 STAT3 STAT5)
INOH website IL-7 signaling pathway (JAK1 JAK3 STAT5) - IL-7 signaling (JAK1 JAK3 STAT5)
INOH website JAK-STAT pathway and regulation pathway - JAK-STAT pathway and regulation pathway Diagram
INOH website Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway - JAK-STAT pathway and regulation pathway Diagram
INOH website VEGF signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_12 BCR pathway
NetPath_16 IL4 pathway
NetPath_17 IL5 pathway
NetPath_18 IL6 pathway
NetPath_6 KitReceptor pathway
REACTOME
REACT_118700 Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
REACT_147814 DAP12 signaling
REACT_6788 MyD88:Mal cascade initiated on plasma membrane
REACT_160086 Regulation of actin dynamics for phagocytic cup formation
KEGG
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04380  Osteoclast differentiation
hsa05340  Primary immunodeficiency
INOH
INOH website AKT(PKB)-Bad signaling - EPO signaling pathway (JAK2 STAT1 STAT3 STAT5)
INOH website AKT(PKB)-Bad signaling - IL-7 signaling (JAK1 JAK3 STAT5)
INOH website EPO signaling pathway (JAK2 STAT1 STAT3 STAT5)
INOH website IL-7 signaling pathway (JAK1 JAK3 STAT5) - IL-7 signaling (JAK1 JAK3 STAT5)
INOH website JAK-STAT pathway and regulation pathway - JAK-STAT pathway and regulation pathway Diagram
INOH website Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway - JAK-STAT pathway and regulation pathway Diagram
INOH website VEGF signaling pathway
PID BIOCARTA
100227 Bcr signaling pathway [Biocarta view]
100165 Fc epsilon receptor i signaling in mast cells [Biocarta view]
100059 Phosphoinositides and their downstream targets [Biocarta view]
PID NCI
bcr_5pathway BCR signaling pathway
epopathway EPO signaling pathway
faspathway FAS (CD95) signaling pathway
fcer1pathway Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt P35991 
TrEMBL A2BDV9 A2BDW0
UniProt Splice Variant
Entrez Gene 12229 
UniGene Mm.4475
RefSeq NM_013482 
OMIM
CCDS CCDS30396 
HPRD
IMGT
MGI ID MGI:88216 
MGI Symbol Btk
EMBL AL672064 BX004852 CH466598 L08967 L10627 L29788 U58105
GenPept AAA37316  AAA66943  AAB47246  CAM19133  CAM19134  CAM27312  CAM27313  EDL20395 
ImmGen Btk (murine) 
RNA Seq Atlas 12229