Version 5.4
Homo sapiens Gene: CLEC6A
Summary
InnateDB Gene IDBG-17145.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC6A
Gene Name C-type lectin domain family 6, member A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000205846
Encoded Proteins
IDBP-17147
C-type lectin domain family 6, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20493731
CLEC6A (Dectin-2) recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defence against Candida albicans.
PMID 21267996
CLEC6A, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. CLEC6A is coupled to SYK kinase and signals via CARD9 to activate NFKB, which in turns induces both innate and adaptive immunity.
PMID 21357742
CLEC6A is critical for the development of house dust mite (Dermatophagoides farinae) elicited eosinophilic and neutrophilic pulmonary inflammation. CLEC6A was also found to be crucial for the Th2 cytokine induction in the lungs and re-stimulated lymph nodes.
PMID 21677049
CLEC6A is expressed mainly in DCs and macrophages. CLEC6A recognizes alpha-mannans with its carbohydrate recognition domain and transduces signals through association with the ITAM-containing Fc receptor gamma chain, which recruits SYK and initiates the CARD9/NFkB signalling cascade.
PMID 23911656
CLEC4D and CLEC6A form a heterodimer complex which confers innate cells high ability to sense C. albicans infection by facilitating the activation of NFκB dependent inflammatory responses.
PMID 25659141
Plasmacytoid dendritic cells (pDCs) directly recognize Aspergillus fumigatus hyphae via CLEC6A; this interaction results in antifungal activity and the formation of pDC extracellular traps.
InnateDB Annotation from Orthologs
Summary
PMID 21267996
[Mus musculus] Clec4n, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. Clec4n is coupled to Syk kinase and signals via Card9 to activate NFKB, which in turns induces both innate and adaptive immunity.
PMID 21357742
[Mus musculus] Clec4n is critical for the development of house dust mite (Dermatophagoides farinae) elicited eosinophilic and neutrophilic pulmonary inflammation. Clec4n was also found to be crucial for the Th2 cytokine induction in the lungs and re-stimulated lymph nodes.
PMID 21677049
[Mus musculus] Clec4n is expressed mainly in DCs and macrophages. Clec4n recognizes alpha-mannans with its carbohydrate recognition domain and transduces signals through association with the ITAM-containing Fc receptor gamma chain, which recruits Syk and initiates the Card9/NFkB signalling cascade.
PMID 27194783
[Mus musculus] Pik3cd regulates Clec4n signalling and the generation of Th2 and Th17 immunity.
Entrez Gene
Summary Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain (Kanazawa et al., 2004 [PubMed 15175046]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8455926-8478330
Strand Forward strand
Band p13.31
Transcripts
ENST00000382073 ENSP00000371505
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0050715 positive regulation of cytokine secretion
GO:0050832 defense response to fungus
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023349
View Gene Order
ENSBTAG00000023635
Not yet available
Cross-References
SwissProt Q6EIG7
TrEMBL
UniProt Splice Variant
Entrez Gene 93978
UniGene Hs.591147
RefSeq NM_001007033
HUGO HGNC:14556
OMIM 613579
CCDS CCDS31739
HPRD
IMGT
EMBL AC092746 AC092865 AY321309 AY365135 BC132933 BC132935
GenPept AAI32934 AAI32936 AAQ83725 AAR13071
RNA Seq Atlas 93978

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca