Version 5.4
Homo sapiens Gene: NOMO2
Summary
InnateDB Gene IDBG-17148.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOMO2
Gene Name NODAL modulator 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185164
Encoded Proteins
IDBP-17150
NODAL modulator 2
IDBP-17152
NODAL modulator 2
IDBP-589251
NODAL modulator 2
IDBP-750670
IDBP-753514
IDBP-754514
IDBP-754332
IDBP-812641
NODAL modulator 2
IDBP-812642
NODAL modulator 2
IDBP-812643
NODAL modulator 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:18417325-18562211
Strand Reverse strand
Band p12.3
Transcripts
ENST00000330537 ENSP00000331851
ENST00000381474 ENSP00000370883
ENST00000543392 ENSP00000439970
ENST00000564991 ENSP00000457351
ENST00000564355
ENST00000569526
ENST00000562312 ENSP00000454412
ENST00000569051 ENSP00000455456
ENST00000567831 ENSP00000454780
ENST00000622306 ENSP00000478653
ENST00000621364 ENSP00000477502
ENST00000620440 ENSP00000477774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q5JPE7
TrEMBL
UniProt Splice Variant
Entrez Gene 283820
UniGene Hs.595893
RefSeq XM_006710251 NM_001004060 NM_173614 XM_006720996
HUGO HGNC:22652
OMIM 609158
CCDS CCDS10570 CCDS32394
HPRD 12375
IMGT
EMBL AC126755 AC136618 AL832855 BC028389 BC041131
GenPept AAH28389 AAH41131 CAI46162
RNA Seq Atlas 102723728 283820

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca