Version 5.4
Homo sapiens Gene: GDNF
Summary
InnateDB Gene IDBG-17169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GDNF
Gene Name glial cell derived neurotrophic factor
Synonyms ATF1; ATF2; HFB1-GDNF; HSCR3
Species Homo sapiens
Ensembl Gene ENSG00000168621
Encoded Proteins
IDBP-17173
glial cell derived neurotrophic factor
IDBP-17175
glial cell derived neurotrophic factor
IDBP-17179
glial cell derived neurotrophic factor
IDBP-365335
glial cell derived neurotrophic factor
IDBP-473606
glial cell derived neurotrophic factor
IDBP-476252
glial cell derived neurotrophic factor
IDBP-475775
glial cell derived neurotrophic factor
IDBP-813434
glial cell derived neurotrophic factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:37812677-37839686
Strand Reverse strand
Band p13.2
Transcripts
ENST00000381826 ENSP00000371248
ENST00000326524 ENSP00000317145
ENST00000344622 ENSP00000339703
ENST00000427982 ENSP00000409007
ENST00000515058 ENSP00000425928
ENST00000502572 ENSP00000423557
ENST00000510177 ENSP00000424592
ENST00000620847 ENSP00000478722
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001755 neural crest cell migration
GO:0001759 organ induction
GO:0001941 postsynaptic membrane organization
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007422 peripheral nervous system development
GO:0008344 adult locomotory behavior
GO:0021784 postganglionic parasympathetic nervous system development
GO:0030432 peristalsis
GO:0031175 neuron projection development
GO:0032770 positive regulation of monooxygenase activity
GO:0033603 positive regulation of dopamine secretion
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048255 mRNA stabilization
GO:0048484 enteric nervous system development
GO:0048485 sympathetic nervous system development
GO:0051584 regulation of dopamine uptake involved in synaptic transmission
GO:0060676 ureteric bud formation
GO:0060688 regulation of morphogenesis of a branching structure
GO:0072107 positive regulation of ureteric bud formation
GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022144
View Gene Order
ENSBTAG00000005176
Not yet available
Pathways
NETPATH
REACTOME
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
ret_pathway
Signaling events regulated by Ret tyrosine kinase
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.248114 Hs.609874
RefSeq NM_000514 NM_001190468 NM_001190469 NM_001278098 NM_199231
HUGO
OMIM
CCDS CCDS3922 CCDS3923 CCDS54845 CCDS54846 CCDS75237
HPRD 02906
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca