InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cxadr

Summary

InnateDB Gene

IDBG-171952.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxadr

Gene Name

coxsackie virus and adenovirus receptor

Synonyms

2610206D03Rik; AU016810; AW553441; CAR; MCAR; MCVADR

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022865

Encoded Proteins

IDBP-171954

coxsackie virus and adenovirus receptor

IDBP-252204

coxsackie virus and adenovirus receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is part of the Cortical Thymocyte marker in Xenopus (CTX) subfamily within the immunoglobulin superfamily. Members of this subfamily, predominantly expressed on the surface of endothelial and epithelial cells, help establish cell polarity and provide a barrier function, regulating migration of immune cells. This protein, first identified as the receptor for adenovirus subgroup C and coxsakieviruses group B, is developmentally regulated and plays an important role in cardiac development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:78301496-78359785

Strand

Forward strand

Band

C3.1

Transcripts

ENSMUST00000023572	ENSMUSP00000023572
ENSMUST00000114229	ENSMUSP00000109867

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0030165	PDZ domain binding
GO:0042802	identical protein binding
GO:0050839	cell adhesion molecule binding
GO:0071253	connexin binding

Biological Process

GO:0007005	mitochondrion organization
GO:0007157	heterophilic cell-cell adhesion
GO:0007507	heart development
GO:0008354	germ cell migration
GO:0010669	epithelial structure maintenance
GO:0016337	single organismal cell-cell adhesion
GO:0030593	neutrophil chemotaxis
GO:0031532	actin cytoskeleton reorganization
GO:0034109	homotypic cell-cell adhesion
GO:0045216	cell-cell junction organization
GO:0046629	gamma-delta T cell activation
GO:0048739	cardiac muscle fiber development
GO:0051607	defense response to virus
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
GO:0070633	transepithelial transport
GO:0086067	AV node cell to bundle of His cell communication

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005923	tight junction
GO:0014704	intercalated disc
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0030175	filopodium
GO:0030426	growth cone
GO:0031594	neuromuscular junction
GO:0043005	neuron projection
GO:0043234	protein complex
GO:0044297	cell body
GO:0045121	membrane raft