InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IRF7

Summary

InnateDB Gene

IDBG-17225.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF7

Gene Name

interferon regulatory factor 7

Synonyms

IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H

Species

Homo sapiens

Ensembl Gene

ENSG00000185507

Encoded Proteins

IDBP-17229

interferon regulatory factor 7

IDBP-17233

interferon regulatory factor 7

IDBP-235069

interferon regulatory factor 7

IDBP-235071

interferon regulatory factor 7

IDBP-235073

interferon regulatory factor 7

IDBP-586326

interferon regulatory factor 7

IDBP-595654

interferon regulatory factor 7

IDBP-585263

interferon regulatory factor 7

IDBP-583198

interferon regulatory factor 7

IDBP-587583

interferon regulatory factor 7

IDBP-589283

interferon regulatory factor 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19152337

IRF7 increases the expression of a broad range of IFN-stimulated genes including immunomodulatory cytokines and genes involved in antigen processing and presentation.

PMID 15664995

IRF7 is activated in response to virus infection and stimulates the transcription of a set of cellular genes involved in host antiviral defence.

PMID 15361868

IRF7 forms a complex with MYD88 and TRAF6 and this complex formation, as well as TRAF6-dependent IRF7 ubiquitination, is required for TLR-mediated interferon (IFN)-alpha induction.

PMID 21820332

IRF7 is involved in the innate immune recognition of Plasmodium falciparum AT-rich DNA and in the subsequent induction of type I IFNs. Mice lacking Irf3/Irf7 are resistant to otherwise lethal cerebral malaria. (Demonstrated in mouse)

PMID 25505178

Coronavirus engages papain-like proteases to escape from the innate antiviral response of the host by inhibiting TP53-IRF7-IFNB1 signalling.

PMID 25520509

Paramyxoviruses trigger the DNA-damage response, a pathway required for RPS6KA5 activation of phospho Ser 276 RELA formation to trigger the IRF7-DDX58 amplification loop necessary for mucosal interferon production.

PMID 25911105

AIP is a novel inhibitor of IRF7 and a negative regulator of innate antiviral signalling.

InnateDB Annotation from Orthologs

Summary

PMID 21820332

[Mus musculus] Irf7 is involved in the innate immune recognition of Plasmodium falciparum AT-rich DNA and in the subsequent induction of type I IFNs. Mice lacking Irf3/Irf7 are resistant to otherwise lethal cerebral malaria.

PMID 24362933

[Mus musculus] Plasmodium RNA is a pathogen-associated molecular pattern (PAMP) capable of activating a type I IFN response via the cytosolic pattern recognition receptors Ifih1 and Mavs, as well as via transcription factors Irf3 and Irf7.

PMID 25531441

[Mus musculus] Genetic deletion of Eif4ebp1 or Eif4ebp2 potentiates innate antiviral immunity by enhancing translation of Irf7.

PMID 26590319

[Mus musculus] DNA vaccine-induced, Irf7-dependent signalling, as part of the Tmem173 (Sting) pathway, is critical for generation of both innate cytokine signalling and antigen-specific B and T cell responses.

Entrez Gene

Summary

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:612553-615999

Strand

Reverse strand

Band

p15.5

Transcripts

ENST00000330243	ENSP00000329411
ENST00000348655	ENSP00000331803
ENST00000397574	ENSP00000380704
ENST00000397570	ENSP00000380700
ENST00000397566	ENSP00000380697
ENST00000469048	ENSP00000434607
ENST00000525445	ENSP00000434009
ENST00000533182	ENSP00000433903
ENST00000528413
ENST00000531912
ENST00000532326	ENSP00000436696
ENST00000525750
ENST00000532788	ENSP00000432403
ENST00000527160
ENST00000532096
ENST00000533190	ENSP00000434524

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 122 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	122 [view]
Protein-Protein	79 [view]
Protein-DNA	43 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0002819	regulation of adaptive immune response
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0009615	response to virus
GO:0016064	immunoglobulin mediated immune response
GO:0019043	establishment of viral latency
GO:0019221	cytokine-mediated signaling pathway
GO:0032479	regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0032607	interferon-alpha production
GO:0032608	interferon-beta production
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0034127	regulation of MyD88-independent toll-like receptor signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0039530	MDA-5 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045351	type I interferon biosynthetic process
GO:0045655	regulation of monocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050776	regulation of immune response
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060340	positive regulation of type I interferon-mediated signaling pathway
GO:2000110	negative regulation of macrophage apoptotic process