Version 5.4
Mus musculus Gene: Pitx3
Summary
InnateDB Gene IDBG-172274.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pitx3
Gene Name paired-like homeodomain transcription factor 3
Synonyms ak; Ptx3
Species Mus musculus
Ensembl Gene ENSMUSG00000025229
Encoded Proteins
IDBP-172276
paired-like homeodomain transcription factor 3
IDBP-621947
paired-like homeodomain transcription factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107859:
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46135685-46148326
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000026259 ENSMUSP00000026259
ENSMUST00000172980
ENSMUST00000172971 ENSMUSP00000134563
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002088 lens development in camera-type eye
GO:0002089 lens morphogenesis in camera-type eye
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007626 locomotory behavior
GO:0010468 regulation of gene expression
GO:0030901 midbrain development
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048666 neuron development
GO:0070306 lens fiber cell differentiation
GO:0071542 dopaminergic neuron differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107859
View Gene Order
ENSBTAG00000015702
Not yet available
Cross-References
SwissProt O35160
TrEMBL G3UZN3
UniProt Splice Variant
Entrez Gene 18742
UniGene Mm.6255
RefSeq NM_008852 XM_006526764
OMIM
CCDS CCDS29872
HPRD
IMGT
MGI ID MGI:1100498
MGI Symbol Pitx3
EMBL AC140233 AF005772 BC120844 BC137810
GenPept AAB87380 AAI20845 AAI37811
RNA Seq Atlas 18742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca