Version 5.4
Mus musculus Gene: Gipc1
Summary
InnateDB Gene IDBG-172301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gipc1
Gene Name GIPC PDZ domain containing family, member 1
Synonyms GIPC; Glut1CIP; Rgs19ip1; Semcap1; TaxIP2; TIP-2
Species Mus musculus
Ensembl Gene ENSMUSG00000019433
Encoded Proteins
IDBP-172303
GIPC PDZ domain containing family, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123159:
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:83652678-83664788
Strand Forward strand
Band C2
Transcripts
ENSMUST00000019577 ENSMUSP00000019577
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005096 GTPase activator activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0017022 myosin binding
GO:0030165 PDZ domain binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006605 protein targeting
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007268 synaptic transmission
GO:0014047 glutamate secretion
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031647 regulation of protein stability
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032467 positive regulation of cytokinesis
GO:0043542 endothelial cell migration
GO:0043547 positive regulation of GTPase activity
GO:0048167 regulation of synaptic plasticity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005903 brush border
GO:0005938 cell cortex
GO:0008021 synaptic vesicle
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030139 endocytic vesicle
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000123159
View Gene Order
ENSBTAG00000000764
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
syndecan_4_pathway
Syndecan-4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.20945 Mm.406056
RefSeq NM_018771
OMIM
CCDS CCDS22457
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca