InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ctsb

Summary

InnateDB Gene

IDBG-172314.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctsb

Gene Name

cathepsin B

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021939

Encoded Proteins

IDBP-172316

cathepsin B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21145045

Ctsb is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. Tlr2, 3, 4 ligand engagement increases the proteolytic activities of Ctsb in macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 18762176

[Homo sapiens] CTSB is a member of the Cathepsins protein family which are key modulators of cell death and inflammatory responses.

PMID 21145045

[Homo sapiens] CTSB is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. TLR2, 3, 4 ligand engagement increases the proteolytic activities of CTSB in macrophages without changing the mRNA expression or the endogenous inhibitors of CTSB. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164733:
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:63122462-63145919

Strand

Forward strand

Band

Transcripts

ENSMUST00000006235

ENSMUSP00000006235

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0043394	proteoglycan binding

Biological Process

GO:0006508	proteolysis
GO:0030574	collagen catabolic process
GO:0030855	epithelial cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0046697	decidualization
GO:0050790	regulation of catalytic activity
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0097067	cellular response to thyroid hormone stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome