Version 5.4
Mus musculus Gene: Thbs4
Summary
InnateDB Gene IDBG-172328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Thbs4
Gene Name thrombospondin 4
Synonyms TSP4
Species Mus musculus
Ensembl Gene ENSMUSG00000021702
Encoded Proteins
IDBP-172330
thrombospondin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113296:
The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:92751590-92794818
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000022213 ENSMUSP00000022213
ENSMUST00000168299
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006986 response to unfolded protein
GO:0007155 cell adhesion
GO:0016525 negative regulation of angiogenesis
GO:0034103 regulation of tissue remodeling
GO:0034976 response to endoplasmic reticulum stress
GO:0048266 behavioral response to pain
GO:0048771 tissue remodeling
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051451 myoblast migration
GO:0051781 positive regulation of cell division
GO:0071603 endothelial cell-cell adhesion
GO:0090023 positive regulation of neutrophil chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0016529 sarcoplasmic reticulum
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113296
View Gene Order
ENSBTAG00000012866
Not yet available
Pathways
NETPATH
REACTOME
REACT_263353
Signaling by PDGF pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04512
ECM-receptor interaction pathway
mmu04510
Focal adhesion pathway
mmu05144
Malaria pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16888
Signaling by PDGF pathway
REACT_111102
Signal Transduction pathway
REACT_204365
Signaling by PDGF pathway
REACT_214353
Signal Transduction pathway
KEGG
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05144
Malaria pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.20865
RefSeq NM_011582
OMIM
CCDS CCDS26684
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca