Version 5.4
Homo sapiens Gene: TXK
Summary
InnateDB Gene IDBG-17234.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXK
Gene Name TXK tyrosine kinase
Synonyms BTKL; PSCTK5; PTK4; RLK; TKL
Species Homo sapiens
Ensembl Gene ENSG00000074966
Encoded Proteins
IDBP-17238
TXK tyrosine kinase
IDBP-479558
TXK tyrosine kinase
IDBP-482620
TXK tyrosine kinase
IDBP-482926
TXK tyrosine kinase
IDBP-480264
TXK tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:48066393-48134256
Strand Reverse strand
Band p12
Transcripts
ENST00000264316 ENSP00000264316
ENST00000514937 ENSP00000422139
ENST00000507351 ENSP00000423481
ENST00000509681 ENSP00000424070
ENST00000510457
ENST00000506073 ENSP00000422798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001012 RNA polymerase II regulatory region DNA binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001816 cytokine production
GO:0001865 NK T cell differentiation
GO:0002250 adaptive immune response
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007202 activation of phospholipase C activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0032609 interferon-gamma production
GO:0032633 interleukin-4 production
GO:0032729 positive regulation of interferon-gamma production
GO:0046777 protein autophosphorylation
GO:0050852 T cell receptor signaling pathway
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054892
View Gene Order
ENSBTAG00000005055
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_6900
Immune System pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
KEGG
hsa04670
Leukocyte transendothelial migration pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6R9F2
UniProt Splice Variant
Entrez Gene 7294
UniGene Hs.479669
RefSeq NM_003328
HUGO HGNC:12434
OMIM 600058
CCDS CCDS3480
HPRD 02505
IMGT
EMBL AC079118 AC096749
GenPept
RNA Seq Atlas 7294

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca