InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc22a5

Summary

InnateDB Gene

IDBG-172348.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc22a5

Gene Name

solute carrier family 22 (organic cation transporter), member 5

Synonyms

jvs; Lstpl; Octn2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018900

Encoded Proteins

IDBP-172350

solute carrier family 22 (organic cation transporter), member 5

IDBP-534173

solute carrier family 22 (organic cation transporter), member 5

IDBP-542338

solute carrier family 22 (organic cation transporter), member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197375:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:53864542-53891660

Strand

Reverse strand

Band

B1.3

Transcripts

ENSMUST00000019044	ENSMUSP00000019044
ENSMUST00000152084	ENSMUSP00000115474
ENSMUST00000136307	ENSMUSP00000118900

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0015075	ion transmembrane transporter activity
GO:0015226	carnitine transmembrane transporter activity
GO:0015293	symporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006814	sodium ion transport
GO:0007005	mitochondrion organization
GO:0007512	adult heart development
GO:0007626	locomotory behavior
GO:0009437	carnitine metabolic process
GO:0015697	quaternary ammonium group transport
GO:0015879	carnitine transport
GO:0034220	ion transmembrane transport
GO:0048608	reproductive structure development
GO:0055085	transmembrane transport
GO:1902603	carnitine transmembrane transport