InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acsl3

Summary

InnateDB Gene

IDBG-172590.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acsl3

Gene Name

acyl-CoA synthetase long-chain family member 3

Synonyms

2610510B12Rik; Acs3; C85929; Facl3; Pro2194

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032883

Encoded Proteins

IDBP-172592

acyl-CoA synthetase long-chain family member 3

IDBP-541231

acyl-CoA synthetase long-chain family member 3

IDBP-537724

acyl-CoA synthetase long-chain family member 3

IDBP-541478

acyl-CoA synthetase long-chain family member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123983:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92%% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:78657825-78707743

Strand

Forward strand

Band

Transcripts

ENSMUST00000035779	ENSMUSP00000045291
ENSMUST00000134566	ENSMUSP00000117952
ENSMUST00000142704	ENSMUSP00000121695
ENSMUST00000135642	ENSMUSP00000116576
ENSMUST00000132997
ENSMUST00000154777
ENSMUST00000148608

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005524	ATP binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0007420	brain development
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0014070	response to organic cyclic compound
GO:0034379	very-low-density lipoprotein particle assembly
GO:0042998	positive regulation of Golgi to plasma membrane protein transport
GO:0044539	long-chain fatty acid import
GO:0051047	positive regulation of secretion
GO:2001247	positive regulation of phosphatidylcholine biosynthetic process

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005811	lipid particle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000123983

View Gene Order

ENSBTAG00000017258

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03320

PPAR signaling pathway pathway

mmu00061

Fatty acid biosynthesis pathway

mmu04920

Adipocytokine signaling pathway pathway

mmu00071

Fatty acid degradation pathway

mmu04146

Peroxisome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_380

Synthesis of very long-chain fatty acyl-CoAs pathway

REACT_1319

Fatty Acyl-CoA Biosynthesis pathway

REACT_1190

Triglyceride Biosynthesis pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00061

Fatty acid biosynthesis pathway

hsa00071

Fatty acid degradation pathway

hsa03320

PPAR signaling pathway pathway

hsa04920

Adipocytokine signaling pathway pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

Q9CZW4

TrEMBL

D3Z4I4 E9PUC2

UniProt Splice Variant

Entrez Gene

74205

UniGene

Mm.276016 Mm.401353

RefSeq

NM_028817 NM_001033606 NM_001136222

OMIM

CCDS

CCDS15087 CCDS48295

HPRD

IMGT

MGI ID

MGI:1921455

MGI Symbol

Acsl3

EMBL

AC156613 AK012088 AK161708 BC031529 CH466548

GenPept

AAH31529 BAB28022 BAE36543 EDL00440 EDL00441

RNA Seq Atlas

74205