Version 5.4
Homo sapiens Gene: FZR1
Summary
InnateDB Gene IDBG-17274.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FZR1
Gene Name fizzy/cell division cycle 20 related 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105325
Encoded Proteins
IDBP-17278
fizzy/cell division cycle 20 related 1 (Drosophila)
IDBP-240237
fizzy/cell division cycle 20 related 1 (Drosophila)
IDBP-364190
fizzy/cell division cycle 20 related 1 (Drosophila)
IDBP-762854
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3506273-3538330
Strand Forward strand
Band p13.3
Transcripts
ENST00000313639 ENSP00000321800
ENST00000395095 ENSP00000378529
ENST00000441788 ENSP00000410369
ENST00000586212
ENST00000592214
ENST00000588327
ENST00000591290 ENSP00000467967
ENST00000588084
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 123 [view]
Protein-Protein 123 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006281 DNA repair
GO:0007067 mitotic nuclear division
GO:0008284 positive regulation of cell proliferation
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031572 G2 DNA damage checkpoint
GO:0040020 regulation of meiosis
GO:0045732 positive regulation of protein catabolic process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051488 activation of anaphase-promoting complex activity
GO:0070306 lens fiber cell differentiation
GO:0070979 protein K11-linked ubiquitination
GO:0090344 negative regulation of cell aging
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005829 cytosol
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020235
View Gene Order
ENSBTAG00000031387
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_6785
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_6867
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_6821
SCF-beta-TrCP mediated degradation of Emi1 pathway
REACT_6875
Phosphorylation of Emi1 pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_383
DNA Replication pathway
REACT_120956
Cellular responses to stress pathway
REACT_2014
Synthesis of DNA pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_899
S Phase pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_829
Regulation of DNA replication pathway
KEGG
hsa04110
Cell cycle pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
INOH
PID NCI
aurora_a_pathway
Aurora A signaling
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.413133
RefSeq NM_001136197 NM_001136198 NM_016263 XM_005259573 XM_006722764
HUGO
OMIM
CCDS CCDS12109 CCDS45916 CCDS45917
HPRD 04687
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca